A Comprehensive Understanding of Model Lipid Membranes: Concepts to Applications

Journal of the Korean Chemical Society

article

Sonam Baghel¹  Monika Khurana¹ 

[1] Department of Applied Sciences, School of Engineering &Technology, Sushant University

关键词: Liposomes;    Phospholipids;    Bilayers;    Fluidity;    Lipid membrane;   

DOI  :  10.5012/jkcs.2023.67.2.89

学科分类：化学（综合）

来源: Korean Chemical Society

【 摘 要 】

The cell membrane, also known as the biological membrane, surrounds every living cell. The main components ofcell membranes are lipids and therefore called as lipid membranes. These membranes are mainly made up of a two-dimensionallipid bilayer along with integral and peripheral proteins. The complex nature of lipid membranes makes it difficult to study andhence artificial lipid membranes are prepared which mimic the original lipid membranes. These artificial lipid membranes areprepared from phospholipid vesicles (liposomes). The liposomes are formed when self-forming phospholipid bilayer comes incontact with water. Liposomes can be unilamellar or multilamellar vesicles which comprises of phospholipids that can be produced naturally or synthetically. The phospholipids are non-toxic, biodegradable and are readily produced on a large scale. Theseliposomes are mostly used in the drug delivery systems. This paper offers comprehensive literature with insights on developingbasic understanding of lipid membranes from its structure, organization, and phase behavior to its potential use in biomedicalapplications. The progress in the field of artificial membrane models considering methods of preparation of liposomes for mimicking lipid membranes, interactions between the lipid membranes, and characterizing techniques such as UV-visible, FTIR, Calorimetry and X-ray diffraction are explained in a concise manner.

【 授权许可】

Unknown