Synthesis of lipids for development of multifunctional lipid-based drug-carriers

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

卷:21

Article

Zhu, Guodong¹  Alhamhoom, Yahya¹  Cummings, Brian S.¹  Arnold, Robert D.¹ 

[1] Univ Georgia, Dept Pharmaceut & Biomed Sci, Coll Pharm, Athens, GA 30602 USA

关键词: Liposomes;    Phospholipids;    Secretory phospholipase A(2);    Synthesis;   

DOI  :  10.1016/j.bmcl.2011.08.103

来源: Elsevier

【 摘 要 】

A simple approach to synthesize phospholipids to modulate drug release and track lipid-based particulate drug-carriers is described. We synthesized two ether lipids, 1 1-O-hexadecyl-2-pentadenoyl-sn-glycerol- 3-phosphocholine (C31PC) and 2 1-O-hexadecyl-2-pentadenoyl-sn-glycerol-3-phosphomethanol (C31PM), and examined their ability to alter enzymatically triggered release of 6-carboxyfluorescein from liposomes incubated in TRIS buffer or fetal bovine serum solutions. Further, we demonstrated that odd-chain lipids, for example, C31PC, could be identified in rat plasma without interference of endogenous lipids. This approach can be adapted to synthesize a variety of lipids for use in developing and optimizing multifunctional drug-carriers. (C) 2011 Elsevier Ltd. All rights reserved.

【 授权许可】

Free