Therapeutic Potential of Ginger Extract on the Embryotoxicity and Nephrotoxicity Induced by Labetalol in Rat Fetuses

Jordan Journal of Biological Sciences

article

Hend T. El-Borm¹  Marwa S. Gobara¹  Gamal M. Badawy¹ 

[1] Zoology Department, Faculty of Science, Menoufia University

关键词: Ginger;    Labetalol;    Embryotoxicity;    Nephrotoxicity;    Apoptosis;    Cell cycle.;   

DOI  :  10.54319/jjbs/160112

学科分类：生物科学（综合）

来源: Hashemite University, Deanship of Research and Higher Studies

【 摘 要 】

Labetalol is a widely used antihypertensive drug, especially during pregnancy. However, its adverse effects on fetuses are unclear. This study aimed to evaluate the therapeutic role of ginger extract on embryonic and renal toxicity induced by labetalol in 20-day-old rat fetuses. Sixty pregnant rats were divided into four groups. Group I served as the control, group II th threceived 200 mg/kg aqueous extract of ginger orally from the 6 to the 15 day of pregnancy, group III received 300 mg/kg labetalol orally over the same period, and group IV received labetalol and aqueous extract of ginger orally. At the end of the thexperiment, i.e. on the 20 day, renal specimens from the rat fetuses were processed for light and electron microscopic examination and flow cytometric analysis of the cell cycle and apoptosis. Additionally, embryotoxicity and morphological parameters were assessed. The labetalol group showed a significant increase in embryo resorption and high growth retardation in the 20-day-old fetuses. Fetal kidneys displayed renal corpuscles with shrunken, narrowed urinary spaces, podocyte affection, tubular cell degeneration, hemorrhage, and hyalinization of tubules. Flow cytometric analysis demonstrated G0/G1 phase cell cycle arrest and a significant increase in apoptosis and necrosis. Administration of ginger with labetalol prevented most of these morphological, histological, and molecular changes. Prenatal exposure to labetalol caused embryonic and nephrotoxicity when administrated during the organogenesis phase. Ginger ameliorated these toxicities.

【 授权许可】

CC BY