Activity of red dragon fruit (Hylocereus polyrhizus) juices on doxorubicin-induced nephropathy in rats

Sustainable Agriculture Transformation for The Nations Welfare of Indonesia and Malaysia

Prasetyo, B.F.^1 ; Shabrina, H.^2 ; Juniantito, V.^1 ; Wientarsih, I.^1

Departement of Clinic, Reproduction and Pathology, Faculty of Veterinary Medicine, Bogor Agricultural University, Agatis Street, Bogor

16680, Indonesia^1

Veterinary Internship, Bogor Agricultural University, Agatis Street, Bogor

16680, Indonesia^2

关键词: Antineoplastic drugs;    Attenuation capacities;    Intraperitoneally;    Necrotic cells;    Nephrotoxicity;    Protein deposition;    Sprague-Dawley rats;    Tubular cells;   

Others  :  https://iopscience.iop.org/article/10.1088/1755-1315/196/1/012037/pdf
DOI  :  10.1088/1755-1315/196/1/012037

来源: IOP

【 摘 要 】

Nephropathy is a common side effects following treatment by an antineoplastic drug, doxorubicin. Dragon fruitis rich in antioxidants which are also beneficial for supporting effective tissue regeneration and reduce detrimental sequelae of chemotherapy. The aim of this study was to determine attenuation capacities of red dragon fruit juice in doxorubicin (DOX)-induced renal damages, based on histopathological findings. Male Sprague-dawley rats, consist of 18 rats were divided into three groups. Group I was given NaCl 0.9% (saline) at the dose of 0.4 ml/rat intraperitoneally (IP) weekly for 4 weeks. Group II was given DOX to induce nephropathy at the dose 4 mg/kg body weight (BW) IP weekly for 4 weeks. Group III was given DOX at the dose 4 mg. kg BW IP weekly for 4 weeks and red pitaya juice at dose 4 ml/kg perorally (PO) three times daily for 5 weeks. Nephrotoxicity was assessed by counting total glomerular that have protein deposisition and tubular cells necrosis. Treatment in group III significantly (p