Antioxidant and antibacterial activities of Coix lacryma-jobi seed and root oil potential for meningitis treatment

Jordan Journal of Biological Sciences

article

Diky Setya Diningrat¹  Novita Sari Harahap²  Marsal Risfandi²  Zulfahri²  Ayu Nirmala Sari³  Kusdianti⁴ 

[1] Department Biology, Faculty Mathematics and Natural Sciences Universitas Negeri Medan;Departement Sport Sciences, Faculty Sport Sciences, Universitas Negeri Medan;Department Biology, Faculty Science and Technology UIN Ar Raniry;Department Biology, Faculty Education of Mathematics and Natural Sciences Universitas Pendidikan Indonesia

关键词: Coix lacryma-jobi;    antioxidant;    antibacterial;    essential oil;    bacterial meningitis;    phytochemical;    DPPH;    minimum inhibitory;   

DOI  :  10.54319/jjbs/140501

学科分类：生物科学（综合）

来源: Hashemite University, Deanship of Research and Higher Studies

【 摘 要 】

Bacterial meningitis is a dreaded infectious disease in the human pulmonary system caused by bacterial invasion and promoting inflammation. Hanjeli (Coix lacryma-jobi) seed and root oil have antioxidant, anti-inflammatory, and antibacterial properties that can be used in the treatment of bacterial meningitis. The study aims to investigate the potential of oil from C. lacryma-jobi seed and root part for bacterial meningitis treatment. The phytochemical screening was performed using standard protocols. Antibacterial activity and minimum inhibitory concentration (MIC) were conducted by the disc diffusion and two-fold dilution method. The preliminary phytochemical screening of C. lacryma-jobi shows that essential oil of root and seed part contains steroids, carotenoids, tannins, alkaloid salts, reducing compounds, flavonoid, anthracenoid, coumarin derivatives, cardenoid, anthocyanins, and saponins. The determination of total phenolic, tannin contents, and antioxidant in essential oil from the root was significantly higher (p <0.05) than the seed part. The C. lacryma-jobi oil from both parts expressed the highest antimicrobial activity against Streptococcus pneumoniae and Klebsiella pneumoniae. Additionally, the lowest minimum inhibitory concentration (12.5–50 mg/mL) was observed against selected bacteria of meningitis. It is concluded that oil from C. lacryma-jobi root and seed parts contains compounds that might be used in the bacterial meningitis treatment.

【 授权许可】

CC BY