Oxidative Toxic Stress and DNA Damage as a Promising Strategy for Identifying Patients with Nonalcoholic Fatty Liver Disease

Jordan Journal of Biological Sciences

article

Mahshid Abdolmaleki¹  Bahram Sifizarei²  Masoud Saidijam²  Ali Reza Soltanian³  Maziar Ganji⁴  Akram Ranjbar¹ 

[1] Department of Pharmacology and Toxicology, School of Pharmacy, Medicinal Plants and Natural Products Research Center;Department of Internal Medicine, School of Medicine,Hamadan University of Medical Sciences;Department of Biostatistics, School of Public Health and Modeling of Noncommunicable Diseases Research Center, Hamadan University of Medical Sciences;Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences

关键词: paraoxonase 1;    oxidative stress;    DNA damage;    nonalcoholic fatty liver disease (NAFLD);   

DOI  :  10.54319/jjbs/140409

学科分类：生物科学（综合）

来源: Hashemite University, Deanship of Research and Higher Studies

【 摘 要 】

Non-alcoholic fatty liver disease (NAFLD) is considered as one of the common causes of chronic hepatitis and cirrhosis. The present study was performed to determine paraoxonase 1 (PON 1) and arylesterase (ARE) activities, biomarkers of oxidative toxic stress and DNA damage in patients with NAFLD and their suitability for identifying for NAFLD. In this case-control study, 40 NAFLD patients and 40 normal subjects were studied. Abdominal ultrasonography, serum PON 1 and ARE activities, level of lipid peroxidation (LPO), total thiol groups (TTG), total antioxidant capacity (TAC) and DNA damage biomarker were measured in both NAFLD patients and control group. There was a significant increase in salt stimulated PON 1 activity and LPO level in NAFLD patients compared to the control group (P0.05). PON 1 activity and LPO level can be considered as biomarkers for NAFLD diagnosis. Along with these biomarkers, total antioxidant capacity can be used for identifying patients with NAFLD.

【 授权许可】

CC BY