Original research: Prevalence and clinical implications of subretinal fluid in retinal diseases: a real-world cohort study

BMJ Open Ophthalmology

article

Jeff Park¹  Tina Felfeli²  Imaan Z Kherani¹  Filiberto Altomare³  David R Chow³  David T Wong³ 

[1] Temerty Faculty of Medicine , University of Toronto;Dalla Lana School of Public Health , University of Toronto;Department of Ophthalmology and Vision Sciences , University of Toronto;Department of Ophthalmology , St Michael's Hospital

关键词: Retina;    Treatment Medical;    Vision;   

DOI  :  10.1136/bmjophth-2022-001214

学科分类：工业工程学

来源: BMJ Publishing Group

【 摘 要 】

Background/aims To characterise the baseline prevalence of subretinal fluid (SRF) and its effects on anatomical and visual acuity (VA) outcomes in diabetic macular oedema (DME) and retinal vein occlusion (RVO) following anti-vascular endothelial growth factor (VEGF).Methods This is a retrospective cohort study of 122 DME and 54 RVO patients who were initiated on anti-VEGF therapy with real-world variable dosing. The DME and RVO cohorts were subclassified based on the presence of SRF at presentation. Snellen VA was measured and converted to logarithm of the minimum angle of resolution (LogMAR). Changes in VA and central subfield thickness (CST) were assessed up to 24 months.Results SRF was present in 22% and 41% in DME and RVO patients, respectively. In the DME subcohort, eyes with SRF showed an improvement of 0.166 logMAR (1.7 Snellen chart lines) at 12 months and 0.251 logMAR (2.6 Snellen chart lines) at 24 months, which were significantly greater compared with those of the non-SRF group. A significantly greater reduction in CST was noted in the SRF eyes compared with the non-SRF eyes at 3 months and 1 month in the DME and RVO subcohorts, respectively.Conclusion Baseline SRF is a good marker for a greater reduction in CST in both DME and RVO, but an improvement in VA associated with SRF may be only noted in DME.

【 授权许可】

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