PolyvasculaR Evaluation for Cognitive Impairment and vaScular Events (PRECISE)—a population-based prospective cohort study: rationale, design and baseline participant characteristics

Stroke and Vascular Neurology

article

Yuesong Pan¹  Jing Jing¹  Xueli Cai³  Yilong Wang¹  Suying Wang⁴  Xia Meng¹  Chunlai Zeng⁵  Jiong Shi¹  Jiansong Ji⁶  Jinxi Lin¹  Lingchun Lyu⁵  Zhe Zhang¹  Lerong Mei⁴  Shiping Li²  Shan Li⁴  Wanlin Zhu¹  Hao Li¹  Tiemin Wei⁵  Yongjun Wang¹ 

[1] Department of Neurology , Beijing Tiantan Hospital, Capital Medical University;China National Clinical Research Center for Neurological Diseases;Department of Neurology , Lishui Hospital, Zhejiang University School of Medicine;Cerebrovascular Research Lab , Lishui Hospital, Zhejiang University School of Medicine;Department of Cardiology , Lishui Hospital, Zhejiang University School of Medicine;Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research , Lishui Hospital, Zhejiang University School of Medicine

关键词: stroke;    plaque;    MRI;    atherosclerosis;   

DOI  :  10.1136/svn-2020-000411

学科分类：社会科学、人文和艺术（综合）

来源: BMJ Publishing Group

【 摘 要 】

Background and purpose Cardiovascular diseases and dementia are two major diseases in the elderly. Atherosclerosis is associated with future vascular events and cognitive impairment. The PolyvasculaR Evaluation for Cognitive Impairment and vaScular Events (PRECISE) study is a population-based prospective cohort study with comprehensive evaluation of multiterritorial artery stenosis and plaque using advanced vascular imaging techniques and prospective collection of vascular events and cognitive assessments.Methods Between May 2017 and September 2019, the PRECISE study enrolled 3067 community-dwelling adults with ages between 50 and 75 years cluster sampled from six villages and four communities of Lishui city in China. Data are collected in face-to-face interviews at baseline, 2-year and 4-year follow-up visits. Brain MRI including high-resolution sequences for intracranial and carotidal arteries and CT angiography for thoracoabdominal arteries were performed at baseline and will be rescanned after 4 years. Cardiovascular/cerebrovascular events and cognitive assessment will be prospectively collected after the enrollment. Blood and urine samples were collected and biomarkers were tested at baseline.Results A total of 3067 subjects were enrolled, among which 53.5% were female with an average age of 61.2±6.7 years. Among them, 2.8%, 8.1%, 43.1% and 21.6% had a history of stroke, heart diseases, hypertension and diabetes mellitus, respectively.Conclusions The PRECISE study is a population-based prospective cohort study with comprehensive evaluation of atherosclerotic stenosis and plaque using advanced vascular imaging techniques. Data from this cohort provide us an opportunity to precisely evaluate polyvascular atherosclerosis and its association with future vascular events and cognitive impairment.Trial registration number ClinicalTrials.gov Registry (NCT03178448).

【 授权许可】

CC BY-NC|CC BY|CC BY-NC-ND