Differences in atheroma between Caucasian and Asian subjects with anterior stroke: A vessel wall MRI study

Stroke and Vascular Neurology

article

Hiroko Watase¹  Mi Shen²  Binbin Sui³  Peiyi Gao²  Dong Zhang⁵  Jie Sun⁶  Niranjan Balu⁶  Daniel S Hippe⁶  Gail P Jarvik⁷  Xihai Zhao⁸  Rui Li⁸  Shuo Chen⁸  Chun Yuan⁶  Thomas S Hatsukami¹ 

[1] Department of Surgery , University of Washington;Department of Radiology , Beijing Tiantan Hospital, Capital Medical University;Tiantan Neuroimaging Center for Excellence , Beijing Tiantan Hospital, Capital Medical University;Beijing Neurosurgical Institute;Department of Neurosurgery , Beijing Tiantan Hospital, Capital Medical University;Department of Radiology , University of Washington;Department Medicine ,(Medical Genetics) and Genome Sciences , University of Washington;Center for Biomedical Imaging Research, Department of Biomedical Engineering , Tsinghua University

关键词: atherosclerosis;    MRI;    stroke;    vessel wall;    plaque;   

DOI  :  10.1136/svn-2020-000370

学科分类：社会科学、人文和艺术（综合）

来源: BMJ Publishing Group

【 摘 要 】

Background and purpose While extracranial carotid artery stenosis is more common among Caucasians and intracranial artery stenosis is more common among Asians, the differences in atherosclerotic plaque characteristics have not yet been extensively examined. We sought to investigate plaque location and characteristics within extracranial carotid and intracranial arteries in symptomatic Caucasians and Chinese using vessel wall MRI.Methods Subjects with recent anterior circulation ischaemic stroke were recruited and imaged at two sites in the USA and China using similar protocols. Both extracranial carotid and intracranial arteries were reviewed to determine plaque location and characteristics.Results The prevalence of extracranial carotid plaque in Caucasians and Chinese was 73.1% and 49.1%, respectively (p=0.055). Prevalence of intracranial plaque was 38.5% and 69.1% in Caucasians and Chinese, respectively (p=0.02). Furthermore, 42% of Caucasians and 16% of Chinese had high-risk plaque (HRP) features (intraplaque haemorrhage, luminal surface disruption) in the extracranial carotid artery (p=0.03). The prevalence of HRP features in intracranial arteries was not significantly different between the two cohorts (4% vs 11%; p=0.42).Conclusions Differences in the location and characteristics of cerebrovascular atherosclerosis were identified by vessel wall MRI in US Caucasian and Chinese subjects with recent anterior circulation ischaemic stroke. Extracranial carotid plaques with HRP features were more common in Caucasians. Intracranial plaques were more common in Chinese subjects, but no significant difference between the two cohorts in intracranial HRP prevalence was found. Larger studies using vessel wall imaging to investigate racial differences in cerebrovascular disease may inform underlying mechanisms of HRP development and may ultimately help guide appropriate therapy.

【 授权许可】

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