Spontaneous extracranial carotid atherosclerosis evolution in asymptomatic individuals: a three-year prospective study

Arquivos de Neuro-Psiquiatria

Rubens José Gagliardi²  Ibsen Thadeu Damiani²  Rogério Menoncello²  Manoel Carlos Sampaio De Almeida Ribeiro¹ 

[1] ,Santa Casa de São Paulo Faculty of Medical Sciences Cerebrovascular Diseases Division (Atherosclerosis League)

关键词: atherosclerosis;    carotid;    stroke;    plaque;    stenosis;    aterosclerose;    estenose;    carótidas;    doença cerebrovascular;   

DOI  :  10.1590/S0004-282X2004000400009

来源: SciELO

【 摘 要 】

OBJECTIVE: To evaluate the spontaneous evolution of extracranial carotid atherosclerosis in asymptomatic patients who did not present the main risk factors associated to the disease. METHOD:A prospective study including patients of both genders, age ranging from 40 to 70 years, not presenting any signs and symptoms of cerebrovascular disease and without the main atherosclerosis risk factors were included. Patients who were using or had used medication during the follow-up period that could potentially influence in the spontaneous course of atherosclerosis were excluded. The evaluation of the plaque and degree of stenosis were acquired using mode B, 7.5 MHz Doppler ultrasonography (USG). The follow-up was carried out for 36 months, with clinical, neurological, and USG exams repeated in a period of 6 to 8 months. Ninety-six individuals (48 women) completed the study with the presence of plaque, and 52 (26 women) with a degree of stenosis. RESULTS: As to the degree of stenosis, 25% of the patients had worsening, 69% remained stable and 6% improved. When only the presence or absence of plaque was considered, 20% showed worsening (plaque developed during follow-up), 7% improved (disappearance of plaque), and 73% remained stable. No differences were found between the male and female patients. CONCLUSION: These results confirm the dynamic characteristics of plaque. In asymptomatic individuals without specific treatment, spontaneous improvement may occur, however, rarely. These findings may contribute as an assessment criterion when a decision is to be made in high-risk patients.

【 授权许可】

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