Mesenchymal stem cells and cell-free preparations for treating atopic dermatitis

Biocell

article

TRINIDAD MONTERO-VILCHEZ¹  MANUEL SANCHEZ-DIAZ¹  CAROLINA MONTERO-VILCHEZ³  ALVARO SIERRA-SANCHEZ²  SALVADOR ARIAS-SANTIAGO¹ 

[1] Dermatology Department, Virgen de las Nieves University Hospital;Instituto de Investigación Biosanitaria Granada;Pharmacy Department, Virgen de las Nieves University Hospital;Dermatology Department, Faculty of Medicine, University of Granada

关键词: Atopic dermatitis;    Conditioned medium;    Dermatology;    Mesenchymal stem cells;    Stem cells;   

DOI  :  10.32604/biocell.2022.021399

学科分类：仪器

来源: Biocell

【 摘 要 】

Atopic dermatitis (AD) is a chronic cutaneous inflammatory disease caused by an interaction between genetic, immune and epidermal barrier factors. Several treatments can be used to treat this disease but there are patients that do not respond to actual drugs. So, there is a need to develop effective therapies for AD. Mesenchymal stem cells (MSCs) are non-hematopoietic multipotent adult progenitor cells with immunomodulatory power and self-regenerating capacity to repair tissue damage, so they could be a potential effective treatment for AD. MSCs-Conditioned Medium (CM) and MSCs-exosomes are cell-free preparation with molecules secreted by stem cells that could be also beneficial for AD. This viewpoint reviews the actual development of MSCs, MSCs-CM and MSCs-exosomes for treating patients with AD.

【 授权许可】

CC BY