Bratislava Medical Journal | |
Are platelet indices promising ratios for predicting pediatric septic shock prognosis? | |
article | |
Mehmet CELEGEN1  Selman KESICI1  Sinan YAVUZ1  Kubra CELEGEN3  Benan BAYRAKCI4  | |
[1] Department of Pediatric Intensive Care Medicine, Hacettepe University İhsan Doğramacı Children’s Hospital;Life Support Center, Hacettepe University;Department of Pediatrics, Division of Nephrology, Hacettepe University İhsan Doğramacı Children’s Hospital;Pediatric Intensive Care Unit, Hacettepe University İhsan Doğramacı Children’s Hospital | |
关键词: septic shock; mortality; platelet indices; thrombocytopenia; children; | |
DOI : 10.4149/BLL_2022_069 | |
学科分类:医学(综合) | |
来源: AEPress, s.r.o. | |
【 摘 要 】
OBJECTIVES: The aim of the present study was to determine the prognostic value of thrombocytopenia, platelet indices (MPV/PLT and PDW/PLT) in children with septic shock.BACKGROUND: Septic shock is one of the major causes of mortality among children worldwide.METHODS: A retrospective analysis was made of children admitted to the pediatric intensive care unit between November 2010 and December 2019. Two hundred four children were included; they were diagnosed with septic shock according to the international pediatric sepsis consensus conference criteria. The MPV/platelet ratio and PDW/platelet ratios were estimated as the MPV and PDW values divided by the platelet count on the first three days of hospitalization. The clinical outcome was 28-day mortality.RESULTS: MPV/PLT and PDW/PLT ratios were found to be significantly higher in the non-survivors than survivor (p≤0.001). In the multivariate logistic regression analysis, higher MPV/platelet ratios at 72h (OR: 7.41; 95% CI: 1.25–43.7; p=0.027) and PDW/platelet ratios at 72h (OR: 2.9; 95% CI: 1.13–7.50; p=0.027) were significant risk factors for mortality. CONCLUSIONS: Platelet indices are useful laboratory parameters in septic shock. MPV/PLT and PDW/PLT ratios can be promising reliable markers for 28-day mortality in children with septic shock (Tab. 4, Fig. 1, Ref. 29).
【 授权许可】
CC BY
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