International Journal of Molecular Sciences | |
Platelets and Multi-Organ Failure in Sepsis | |
Barbara Vizio1  Elisabetta Greco1  Giuseppe Montrucchio1  Ornella Bosco1  Enrico Lupia1  | |
[1] Department of Medical Science, University of Turin, 10126 Turin, Italy; | |
关键词: platelet; sepsis; multi-organ failure; thrombocytopenia; septic shock; antiplatelets; ARDS; AKI; DIC; | |
DOI : 10.3390/ijms18102200 | |
来源: DOAJ |
【 摘 要 】
Platelets have received increasing attention for their role in the pathophysiology of infectious disease, inflammation, and immunity. In sepsis, a low platelet count is a well-known biomarker for disease severity and more recently authors have focused their attention on the active role of platelets in the pathogenesis of multi-organ failure. Septic shock is characterised by a dysregulated inflammatory response, which can impair the microcirculation and lead to organ injury. Being at the crossroads between the immune system, clotting cascade, and endothelial cells, platelets seem to be an appealing central mediator and possible therapeutic target in sepsis. This review focuses on the pathogenic role of platelets in septic organ dysfunction in humans and animal models.
【 授权许可】
Unknown