Platelets and Multi-Organ Failure in Sepsis

International Journal of Molecular Sciences

Barbara Vizio¹  Elisabetta Greco¹  Giuseppe Montrucchio¹  Ornella Bosco¹  Enrico Lupia¹ 

[1] Department of Medical Science, University of Turin, 10126 Turin, Italy;

关键词: platelet;    sepsis;    multi-organ failure;    thrombocytopenia;    septic shock;    antiplatelets;    ARDS;    AKI;    DIC;   

DOI  :  10.3390/ijms18102200

来源: DOAJ

【 摘 要 】

Platelets have received increasing attention for their role in the pathophysiology of infectious disease, inflammation, and immunity. In sepsis, a low platelet count is a well-known biomarker for disease severity and more recently authors have focused their attention on the active role of platelets in the pathogenesis of multi-organ failure. Septic shock is characterised by a dysregulated inflammatory response, which can impair the microcirculation and lead to organ injury. Being at the crossroads between the immune system, clotting cascade, and endothelial cells, platelets seem to be an appealing central mediator and possible therapeutic target in sepsis. This review focuses on the pathogenic role of platelets in septic organ dysfunction in humans and animal models.

【 授权许可】

Unknown