Are platelet indices promising ratios for predicting pediatric septic shock prognosis?

Bratislava Medical Journal

article

Mehmet CELEGEN¹  Selman KESICI¹  Sinan YAVUZ¹  Kubra CELEGEN³  Benan BAYRAKCI⁴ 

[1] Department of Pediatric Intensive Care Medicine, Hacettepe University İhsan Doğramacı Children’s Hospital;Life Support Center, Hacettepe University;Department of Pediatrics, Division of Nephrology, Hacettepe University İhsan Doğramacı Children’s Hospital;Pediatric Intensive Care Unit, Hacettepe University İhsan Doğramacı Children’s Hospital

关键词: septic shock;    mortality;    platelet indices;    thrombocytopenia;    children;   

DOI  :  10.4149/BLL_2022_069

学科分类：医学（综合）

来源: AEPress, s.r.o.

【 摘 要 】

OBJECTIVES: The aim of the present study was to determine the prognostic value of thrombocytopenia, platelet indices (MPV/PLT and PDW/PLT) in children with septic shock. BACKGROUND: Septic shock is one of the major causes of mortality among children worldwide. METHODS: A retrospective analysis was made of children admitted to the pediatric intensive care unit between November 2010 and December 2019. Two hundred four children were included; they were diagnosed with septic shock according to the international pediatric sepsis consensus conference criteria. The MPV/platelet ratio and PDW/platelet ratios were estimated as the MPV and PDW values divided by the platelet count on the first three days of hospitalization. The clinical outcome was 28-day mortality. RESULTS: MPV/PLT and PDW/PLT ratios were found to be significantly higher in the non-survivors than survivor (p≤0.001). In the multivariate logistic regression analysis, higher MPV/platelet ratios at 72h (OR: 7.41; 95% CI: 1.25–43.7; p=0.027) and PDW/platelet ratios at 72h (OR: 2.9; 95% CI: 1.13–7.50; p=0.027) were significant risk factors for mortality. CONCLUSIONS: Platelet indices are useful laboratory parameters in septic shock. MPV/PLT and PDW/PLT ratios can be promising reliable markers for 28-day mortality in children with septic shock (Tab. 4, Fig. 1, Ref. 29).

【 授权许可】

CC BY