Viral and cellular messenger RNA targets of viral microRNAs

Review

关键词: GENE-EXPRESSION;    IDENTIFICATION;    NEUROVIRULENCE;    TRANSLATION;    INFECTION;    ORTHOLOG;    ENCODES;    PROTEIN;   

DOI  :  10.1038/nature07757

来源: SCIE

【 摘 要 】

Given the propensity of viruses to co- opt cellular pathways and activities for their benefit, it is perhaps not surprising that several viruses have now been shown to reshape the cellular environment by reprogramming the host's RNA- interference machinery. In particular, microRNAs are produced by the various members of the herpesvirus family during both the latent stage of the viral life cycle and the lytic ( or productive) stage. Emerging data suggest that viral microRNAs are particularly important for regulating the transition from latent to lytic replication and for attenuating antiviral immune responses.

【 授权许可】

Free