Anti-vibriosis bioactive molecules from Arctic Penicillium sp. Z2230

Bioresources and Bioprocessing

Research

Huifang Li¹  Bo Guo¹  Di Zhang¹  Song Gao¹  Jiacheng Guo¹  Jin Yang²  Faliang An²  Pei Wang³ 

[1] Jiangsu Key Laboratory of Marine Biological Resources and Environment, Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening, MNR Key Laboratory of Coastal Salt Marsh Ecosystems and Resources, School of Pharmacy, Co-Innovation Center of Jiangsu Marine Bio-Industry Technology, Jiangsu Ocean University, 222005, Lianyungang, China;Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, 130 Meilong Road, 200237, Shanghai, China;School of Food Science and Pharmaceutical Engineering, Nanjing Normal University, 210023, Nanjing, China;

关键词: Arctic endophytic fungus;    Secondary metabolites;    Natural products;    Anti-vibriosis;    Aquaculture;    Antibiotic resistance;   

DOI  :  10.1186/s40643-023-00628-5

 received in 2022-12-01, accepted in 2023-01-09,  发布年份 2023

来源: Springer

【 摘 要 】

Vibrio species (Vibrio sp.) is a class of Gram-negative aquatic bacteria that causes vibriosis in aquaculture, which have resulted in big economic losses. Utilization of antibiotics against vibriosis has brought concerns on antibiotic resistance, and it is essential to explore potential antibiotic alternatives. In this study, seven compounds (compounds 1–7) were isolated from the Arctic endophytic fungus Penicillium sp. Z2230, among which compounds 3, 4, and 5 showed anti-Vibrio activity. The structures of the seven compounds were comprehensively elucidated, and the antibacterial mechanism of compounds 3, 4, and 5 was explored by molecular docking. The results suggested that the anti-Vibrio activity could come from inhibition of the bacterial peptide deformylase (PDF). This study discovered three Penicillium-derived compounds to be potential lead molecules for developing novel anti-Vibrio agents, and identified PDF as a promising antibacterial target. It also expanded the bioactive diversity of polar endophytic fungi by showing an example in which the secondary metabolites of a polar microbe were a good source of natural medicine.Graphical Abstract

【 授权许可】

CC BY   
© The Author(s) 2023

【 图 表 】

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