Regulon active landscape reveals cell development and functional state changes of human primary osteoblasts in vivo

Human Genomics

Research

Qiu Xiang¹  Xianghe Meng¹  Shengran Wang¹  Christopher J. Papasian²  Yisu Li³  Yiping Chen³  Qilan Liang³  Liang Cheng⁴  Yihe Hu⁵  Hongmei Xiao⁶  Ying Liu⁷  Xiaohua Li⁷  Hiuxi Zhang⁷  Lijun Tan⁷  Hongwen Deng⁸  Zhe Luo⁸  Jonathan Greenbaum⁸  Yun Gong⁸  Hui Shen⁸  Zun Wang⁹ 

[1] Center for System Biology, Data Sciences and Reproductive Health, School of Basic Medical Science, Central South University, 410008, Changsha, China;Department of Biomedical Sciences, School of Medicine, University of Missouri-Kansas City, Kansas City, MO, USA;Department of Cell and Molecular Biology, Tulane University School of Science and Engineering, Tulane University, 70112, New Orleans, LA, USA;Department of Orthopaedics and National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, 410008, Changsha, China;Department of Orthopedics, Xiangya Hospital, Central South University, 410008, Changsha, China;Institute of Reproductive and Stem Cell Engineering, Center of Reproductive Health, School of Basic Medical Science, Central South University, 172 Tongzipo Road, Yuelu District, 410013, Changsha, Hunan Province, People’s Republic of China;Center of Reproductive Health, School of Basic Medical Science, Central South University, 410008, Changsha, China;Laboratory of Molecular and Statistical Genetics, College of Life Sciences, Human Normal University, 410081, Changsha, China;Tulane Center of Biomedical Informatics and Genomics, Deming Department of Medicine, Tulane University School of Medicine, Tulane University, 1440 Canal St., Suite 1610, 70112, New Orleans, LA, USA;Xiangya School of Nursing, Central South University, 410013, Changsha, China;

关键词: Osteoblast;    Bone metabolism;    Single-cell RNA sequencing;    Transcription factor;    Cell-specific network;   

DOI  :  10.1186/s40246-022-00448-2

 received in 2022-06-10, accepted in 2022-12-20,  发布年份 2022

来源: Springer

【 授权许可】

CC BY   
© The Author(s) 2023

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