Seroprevalence and risk factors for Kaposi’s Sarcoma associated herpesvirus among men who have sex with men in Shanghai, China

BMC Infectious Diseases

Research

Yi Li¹  Xingcan Zhang²  Sijie Tao³  Ying Yang³  Minqi Wei³  Yue Zhang³ 

[1] Department of Epidemiology, School of Public Health, Fudan University, Shanghai, China;Department of Gynecology, Obstetrics and Gynecology Hospital, Fudan University, 200011, Shanghai, China;Department of HIV/AIDS Prevention, Center for Disease Control and Prevention of Minhang District, 201101, Shanghai, China;

关键词: KSHV;    MSM;    Risk factor;    China;   

DOI  :  10.1186/s12879-023-08028-y

 received in 2022-05-02, accepted in 2023-01-24,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundThis study aimed to facilitate the understanding of the transmission route and risk factors that might contribute to the infection of Kaposi’s sarcoma associated herpesvirus (KSHV) among men who have sex with men (MSM).MethodsA cross-sectional study of 520 subjects was conducted in Shanghai, China in 2020. Plasma samples were collected and screened for KSHV, HIV, HBV, HCV, and syphilis. Univariate and multivariate logistic regression analyses were conducted to explore potential correlates of KSHV infection.ResultsThe overall seroprevalence of KSHV was 43.8%, with an adjusted value of 29.8% according to the sensitivity and specificity of the KSHV screening assay. Individuals with lower levels of monthly income (Chi-sqauretrend = 4.11, P = 0.043) and more male sex partners (Chi-sqauretrend = 6.06, P = 0.014) were more likely to be infected with KSHV. Also, KSHV seropositivity was positively associated with being a student (aOR = 1.96; 95%CI: 1.09–3.61), being coinfected with HCV (aOR = 2.61; 95%CI: 1.05–7.10), and syphilis (aOR = 2.91; 95%CI: 1.30–6.89).ConclusionsThe prevalence of KSHV in MSM remains high. As a risky sexual behavior, having multiple male sex partners is a key contributor to KSHV infection among this population. Efforts designed to control modifiable risk factors in order to reduce the burden of KSHV infection are indispensable. High KSHV seroprevalence among students MSM deserves more attention.

【 授权许可】

CC BY   
© The Author(s) 2023

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