Triglyceride-glucose index and triglyceride to high-density lipoprotein cholesterol ratio as potential cardiovascular disease risk factors: an analysis of UK biobank data

Cardiovascular Diabetology

Research

Chongke Zhong¹  Yonghong Zhang¹  Bizhong Che²  Tian Zhao³  Liyuan Han³  Ruijie Zhang³  Liyuan Pu³ 

[1] Department of Epidemiology, School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Suzhou Medical College of Soochow University, 199 Renai Road, Industrial Park District, 215123, Suzhou, Jiangsu, China;Department of Global Health, Ningbo Institute of Life and Health Industry, University of Chinese Academy of Sciences, 159 Beijiao Road, Jiangbei District, 153000, Ningbo, Zhejiang, China;Department of Epidemiology, School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Suzhou Medical College of Soochow University, 199 Renai Road, Industrial Park District, 215123, Suzhou, Jiangsu, China;Department of Global Health, Ningbo Institute of Life and Health Industry, University of Chinese Academy of Sciences, 159 Beijiao Road, Jiangbei District, 153000, Ningbo, Zhejiang, China;Hwa Mei Hospital, Key Laboratory of Diagnosis and Treatment of Digestive System Tumors of Zhejiang Province, University of Chinese Academy of Sciences, Ningbo, Zhejiang, China;

关键词: Cardiovascular disease;    Insulin resistance;    TyG index;    TG/HDL‑C ratio;    Mediation analysis;   

DOI  :  10.1186/s12933-023-01762-2

 received in 2022-09-24, accepted in 2023-02-03,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundThe triglyceride-glucose (TyG) index and triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio, two simple surrogate indicators of insulin resistance, have been demonstrated to predict cardiovascular disease (CVD). However, very few studies have investigated their associations with CVD in European populations.MethodsA total of 403,335 participants from the UK Biobank with data for TyG index and TG/HDL-C ratio and free from CVD at baseline were included. Cox models were applied to evaluate the association between TyG index and TG/HDL-C ratio and incident CVD. Mediation analyses were performed to evaluate the contribution of prevalent diabetes, hypertension, and dyslipidemia to observed associations.ResultsDuring a median follow-up of 8.1 years, 19,754 (4.9%) individuals developed CVD, including 16,404 (4.1%) cases of CHD and 3976 (1.0%) cases of stroke. The multivariable-adjusted hazard ratios of total CVD in higher quartiles versus the lowest quartiles were 1.05, 1.05, and 1.19, respectively, for TyG index, and 1.07, 1.13, and 1.29, respectively, for TG/HDL-C ratio. There were significant trends toward an increasing risk of CVD across the quartiles of TyG index and TG/HDL-C ratio. In mediation analyses, dyslipidemia, type 2 diabetes, and hypertension explained 45.8%, 27.0%, and 15.0% of TyG index’s association with CVD, respectively, and 40.0%, 11.8%, and 13.3% of TG/HDL-C ratio’s association with CVD, respectively.ConclusionsElevated baseline TyG index and TG/HDL-C ratio were associated with a higher risk of CVD after adjustment for the well-established CVD risk factors. These associations were largely mediated by greater prevalence of dyslipidemia, type 2 diabetes, and hypertension.

【 授权许可】

CC BY   
© The Author(s) 2023

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