Functions and mechanisms of lncRNA MALAT1 in cancer chemotherapy resistance

Biomarker Research

Review

Yuan Wang¹  Xia Wang²  Gong Zhang²  Junhui Hou²  Kefeng Wang² 

[1] Department of General Surgery, Shengjing Hospital of China Medical University, #36 Sanhao Street, Heping District, 110004, Shenyang, Liaoning, China;Department of Urology, Shengjing Hospital of China Medical University, #36 Sanhao Street, Heping District, 110004, Shenyang, Liaoning, China;

关键词: Long non-coding RNA;    MALAT1;    Chemotherapy resistance;    Cancer;    Treatment;   

DOI  :  10.1186/s40364-023-00467-8

 received in 2023-01-12, accepted in 2023-02-17,  发布年份 2023

来源: Springer

【 摘 要 】

Chemotherapy is one of the most important treatments for cancer therapy. However, chemotherapy resistance is a big challenge in cancer treatment. Due to chemotherapy resistance, drugs become less effective or no longer effective at all. In recent years, long non-coding RNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) has been found to be associated with the development of chemotherapy resistance, suggesting that MALAT1 may be an important target to overcome chemotherapy resistance. In this review, we introduced the main mechanisms of chemotherapy resistance associated with MALAT1, which may provide new approaches for cancer treatment.

【 授权许可】

CC BY   
© The Author(s) 2023

【 图 表 】

Fig. 3