BCG-induced trained immunity: history, mechanisms and potential applications

Journal of Translational Medicine

Review

Li Peng¹  Li Gao¹  Jingjing Chen¹  Xinya Wu²  Yuxin Fan²  Bingxue Li²  Meixiao Liu²  Jieqin Song²  Aihua Liu³  Fukai Bao⁴ 

[1] The Institute for Tropical Medicine, Kunming Medical University, 650500, Kunming, Yunnan, China;Department of Biochemistry and Molecular Biology, Kunming Medical University, 650500, Kunming, Yunnan, China;The Institute for Tropical Medicine, Kunming Medical University, 650500, Kunming, Yunnan, China;Department of Microbiology and Immunology, Kunming Medical University, 650500, Kunming, Yunnan, China;The Institute for Tropical Medicine, Kunming Medical University, 650500, Kunming, Yunnan, China;Yunnan Health Cell Biotechnology Company, 650041, Kunming, Yunnan, China;Department of Biochemistry and Molecular Biology, Kunming Medical University, 650500, Kunming, Yunnan, China;The Institute for Tropical Medicine, Kunming Medical University, 650500, Kunming, Yunnan, China;Yunnan Health Cell Biotechnology Company, 650041, Kunming, Yunnan, China;Department of Microbiology and Immunology, Kunming Medical University, 650500, Kunming, Yunnan, China;

关键词: BCG;    Trained immunity;    Epigenetic reprogramming;    Metabolic reprogramming;    Viral infection;    Cancer;   

DOI  :  10.1186/s12967-023-03944-8

 received in 2022-10-03, accepted in 2023-01-31,  发布年份 2023

来源: Springer

【 摘 要 】

The Bacillus Calmette-Guérin (BCG) vaccine was discovered a century ago and has since been clinically applicable. BCG can not only be used for the prevention of tuberculosis, but also has a non-specific protective effect on the human body called trained immunity that is mediated by innate immune cells such as monocytes, macrophages, and natural killer cells. Mechanisms of trained immunity include epigenetic reprogramming, metabolic reprogramming, and long-term protection mediated by hematopoietic stem cells. Trained immunity has so far shown beneficial effects on cancer, viral-infections, autoimmune diseases, and a variety of other diseases, especially bladder cancer, respiratory viruses, and type 1 diabetes. The modulation of the immune response by BCG has led to the development of a variety of recombinant vaccines. Although the specific mechanism of BCG prevention on diseases has not been fully clarified, the potential role of BCG deserves further exploration, which is of great significance for prevention and treatment of diseases.

【 授权许可】

CC BY   
© The Author(s) 2023

【 图 表 】

Fig. 5