The effect of DASH diet on glycemic response, meta-inflammation and serum LPS in obese patients with NAFLD: a double-blind controlled randomized clinical trial

Nutrition & Metabolism

Research

Manuchehr Khoshbaten¹  Helda Tutunchi²  Mehrangiz Ebrahimi-Mameghani³  Farnaz Rooholahzadegan⁴  Taghi Badali⁴  Sara Arefhosseini⁴ 

[1] Department of Internal Medicine, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran;Endocrine Research Center, Tabriz University of Medical Sciences, Tabriz, Iran;Nutrition Research Center, Department of Biochemistry and Diet Therapy, Faculty of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran;Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran;

关键词: Dietary approaches to stop hypertension;    Glycemic control;    Inflammation;    Lipoploysaccharides;    Non-alcoholic fatty liver disease;   

DOI  :  10.1186/s12986-023-00733-4

 received in 2022-09-16, accepted in 2023-02-08,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundAs dietary approaches to stop hypertension (DASH) dietary pattern has been shown to be effective in hypertension and obesity, the present study investigated the effects of following DASH diet on glycemic, meta-inflammation, lipopolysaccharides (LPS) and liver function in obese patients with non-alcoholic fatty liver disease (NAFLD).MethodsIn this double-blind controlled randomized clinical trial, 40 obese patients with NAFLD were randomly allocated into either “DASH diet” (n = 20) or calorie-restricted diet as "Control” (n = 20) group for 8 weeks. Anthropometric measures, blood pressure, glycemic response, liver enzymes, toll-like reseptor-4 (TLR-4) and monocyte chemoattractant protein (MCP-1) and LPS as well as Dixon's DASH diet index were assessed at baseline and after 8 weeks.ResultsAfter 8 weeks, although all obesity indices decreased significantly in both groups, the reduction in all anthropometric measures were significantly greater in DASH vs control group, after adjusting for baseline values and weight change. Fasting glucose level decreased in both group, however, no inter-group significant difference was found at the end of study. Nevertheless, serum levels of hemoglobin A1c (HbA1c), TLR-4, MCP-1 and LPS as well as aspartate aminotransferase (AST) decreased significantly in DASH group, after adjusting for baseline values and weight change (p < 0.001, p = 0.004, p = 0.027, p = 0.011, and p = 0.008, respectively). The estimated number needed to treats (NNTs) for one and two grade reductions in NAFLD severity following DASH diet were 2.5 and 6.67, respectively.ConclusionAdherence to DASH diet could significantly improve weight, glycemia, inflammation and liver function in obese patients with NAFLD.

【 授权许可】

CC BY   
© The Author(s) 2023

【 图 表 】

Fig. 1