The potential use of mesenchymal stem cells-derived exosomes as microRNAs delivery systems in different diseases

Cell Communication and Signaling

Review

Saman Yasamineh¹  Somayeh Vafaei²  Elham Oveili³  Yeganeh Eslami⁴  Ehsan Mamaghanizadeh⁵  Haniyeh Bazavar⁵  Omid Gholizadeh⁶ 

[1] Department of Biotechnology, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran;Department of Molecular Medicine, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran;Department of Pharmaceutical Science, Azad Islamic University of Medical Sciences, Tehran, Iran;Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran;Infectious and Tropical Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran;Infectious and Tropical Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran;Department of Bacteriology and Virology, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran;Research Center for Clinical Virology, Tehran University of Medical Sciences, Tehran, Iran;

关键词: Non-coding RNA;    Mesenchymal stem cells;    Exosomes;    Drug delivery system;   

DOI  :  10.1186/s12964-022-01017-9

 received in 2022-10-14, accepted in 2022-12-14,  发布年份 2022

来源: Springer

【 摘 要 】

MicroRNAs (miRNAs) are a group of small non-coding RNAs that regulate gene expression by targeting mRNA. Moreover, it has been shown that miRNAs expression are changed in various diseases, such as cancers, autoimmune disease, infectious diseases, and neurodegenerative Diseases. The suppression of miRNA function can be easily attained by utilizing of anti-miRNAs. In contrast, an enhancement in miRNA function can be achieved through the utilization of modified miRNA mimetics. The discovery of appropriate miRNA carriers in the body has become an interesting subject for investigators. Exosomes (EXOs) therapeutic efficiency and safety for transferring different cellular biological components to the recipient cell have attracted significant attention for their capability as miRNA carriers. Mesenchymal stem cells (MSCs) are recognized to generate a wide range of EXOs (MSC-EXOs), showing that MSCs may be effective for EXO generation in a clinically appropriate measure as compared to other cell origins. MSC-EXOs have been widely investigated because of their immune attributes, tumor-homing attributes, and flexible characteristics. In this article, we summarized the features of miRNAs and MSC-EXOs, including production, purification, and miRNA loading methods of MSC-EXOs, and the modification of MSC-EXOs for targeted miRNA delivery in various diseases.Graphical abstract4msC4DPLFbtUqpbuDdwiDUVideo abstract

【 授权许可】

CC BY   
© The Author(s) 2023

【 图 表 】

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