Changes in the characteristics of patients treated for brain metastases with repeat stereotactic radiotherapy (SRT): a retrospective study of 184 patients

Radiation Oncology

Research

H. Cebula¹  G. Noel²  A. Keller²  D. Antoni²  L. Kuntz²  C. Le Fèvre²  A. Thiery³  P. Meyer⁴  D. Jarnet⁴ 

[1] Department of Neurosurgery, University Hospitals of Strasbourg, 1 Avenue Molière, 67200, Strasbourg, France;Department of Radiation Therapy, Institut de Cancérologie Strasbourg Europe (ICANS), 17 Rue Albert Calmette, 67200, Strasbourg, France;Medical Information Department, Institut de Cancérologie Strasbourg Europe (ICANS), 3 Rue de La Porte de L’Hôpital, 67065, Strasbourg Cedex, France;Medical Physics Unit, Institut de Cancérologie Strasbourg Europe (ICANS), 17 Rue Albert Calmette, 67200, Strasbourg, France;

关键词: Radiotherapy;    Salvage radiation;    Stereotactic radiosurgery;    Brain metastases;    Reirradiation;    Repeated radiosurgery;    Oligorecurrence;   

DOI  :  10.1186/s13014-023-02200-z

 received in 2022-03-02, accepted in 2023-01-03,  发布年份 2023

来源: Springer

【 摘 要 】

PurposeBrain metastases (BMs) are the leading cause of intracranial malignant neoplasms in adults. WHO, Karnofsky performance status (KPS), age, number of BMs, extracerebral progression (ECP), recursive partitioning analysis (RPA), diagnosis-specific graded prognostic assessment (Ds-GPA) are validated prognostic tools to help clinicians decide on treatment. No consensus exists for repeat stereotactic radiotherapy (SRT) for BMs. The aim of this study was to review the changes in patient characteristics treated with repeated SRTs.Methods and materialsThe data of patients treated between 2010 and 2020 with at least two courses of SRT without previous whole brain radiotherapy (WBRT) were reviewed. Age, WHO, KPS, ECP, type of systemic treatment, number of BMs were recorded. RPA, Ds-GPA and brain metastasis velocity (BMV) were calculated.Results184 patients were treated for 915 BMs and received two to six SRTs for local or distant brain recurrence. The median number of BMs treated per SRT was 1 (range: 1–6), for a median of 4 BMs treated during all sessions (range: 2–19). WHO, Ds-GPA and RPA were stable between each session of SRT, whereas KPS was significantly better in SRT1 than in the following SRT. The number of BMs was not significantly different between each SRT, but there was a tendency for more BM at SRT1 (p = 0.06). At SRT1, patients had largest BM and undergo more surgery than during the following SRT (p < 0.001). 6.5%, 37.5% and 56% of patients were classified as high, intermediate, and low BMV, respectively, at the last SRT session. There was almost perfect concordance between the BMV-grade calculated at the last SRT session and at SRT2 (r = 0.89; p < 0.001).ConclusionRepeated SRT doesn't lead to a marked alteration in the general condition, KPS was maintained at over 70% for more than 95% of patients during all SRTs. Long survival can be expected, especially in low-grade BMV patients. WBRT shouldn't be aborted, especially for patients developing more than twelve BMs annually.

【 授权许可】

CC BY   
© The Author(s) 2023

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