Lifestyle-, environmental-, and additional health factors associated with an increased sperm DNA fragmentation: a systematic review and meta-analysis

Reproductive Biology and Endocrinology

Review

Alex Váradi¹  Attila Forintos¹  Teodóra Filipov²  Nándor Ács³  Szilárd Váncsa⁴  Péter Hegyi⁴  Anett Szabó⁵  Péter Nyirády⁵  Júlia Ács⁵  Zsolt Kopa⁵  Tibor Szarvas⁶ 

[1] Centre for Translational Medicine, Semmelweis University, Budapest, Hungary;Centre for Translational Medicine, Semmelweis University, Budapest, Hungary;Department of Interventional Radiology, Semmelweis University, Budapest, Hungary;Centre for Translational Medicine, Semmelweis University, Budapest, Hungary;Department of Obstetrics and Gynecology, Semmelweis University, Budapest, Hungary;Centre for Translational Medicine, Semmelweis University, Budapest, Hungary;Institute for Translational Medicine, Medical School, University of Pécs, Pécs, Hungary;Institute of Pancreatic Diseases, Semmelweis University, Budapest, Hungary;Department of Urology, Semmelweis University, Üllői Ut 78/B, H-1082, Budapest, Hungary;Centre for Translational Medicine, Semmelweis University, Budapest, Hungary;Department of Urology, Semmelweis University, Üllői Ut 78/B, H-1082, Budapest, Hungary;Centre for Translational Medicine, Semmelweis University, Budapest, Hungary;Department of Urology, University of Duisburg-Essen and German Cancer Consortium, Essen, Germany;

关键词: Male fertility;    Infertility;    Reproductive medicine;    Sperm quality;    Prognostic factors;    DFI;    DNA fragmentation index;    SDF;    Sperm DNA fragmentation;   

DOI  :  10.1186/s12958-023-01054-0

 received in 2022-11-18, accepted in 2023-01-02,  发布年份 2023

来源: Springer

【 摘 要 】

IntroductionInfertility affects one in every six couples in developed countries, and approximately 50% is of male origin. In 2021, sperm DNA fragmentation (SDF) testing became an evidence-based test for fertility evaluations depicting fertility more clearly than standard semen parameters. Therefore, we aimed to summarize the potential prognostic factors of a higher SDF.MethodsWe conducted a systematic search in three medical databases and included studies investigating any risk factors for SDF values. We calculated mean differences (MD) in SDF with 95% confidence interval (CI) for exposed and non-exposed individuals.ResultsWe included 190 studies in our analysis. In the group of associated health conditions, varicocele (MD = 13.62%, CI: 9.39–17.84) and impaired glucose tolerance (MD = 13.75%, CI: 6.99–20.51) had the most significant increase in SDF. Among malignancies, testicular tumors had the highest impact, with a maximum of MD = 11.3% (CI: 7.84–14.76). Among infections, the overall effects of both Chlamydia and HPV were negligible. Of lifestyle factors, smoking had the most disruptive effect on SDF – an increase of 9.19% (CI: 4.33–14.06). Different periods of sexual abstinence did not show significant variations in SDF values. Age seemed to have a more drastic effect on SDF from age 50 onwards, with a mean difference of 12.58% (CI: 7.31–17.86). Pollution also had a detrimental effect – 9.68% (CI: 6.85–12.52).ConclusionOf the above risk factors, varicocele, impaired glucose tolerance, testicular tumors, smoking, pollution, and paternal age of over 50 were associated with the highest SDF.Trial registrationCRD42021282533.

【 授权许可】

CC BY   
© The Author(s) 2023

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