Neurofilament light chain is increased in the parahippocampal cortex and associates with pathological hallmarks in Parkinson’s disease dementia

Translational Neurodegeneration

Research

Frederik Barkhof¹  Annemieke J. M. Rozemuller²  Emma J. M. Hermans³  Yvon Galis-de Graaf³  John G. J. M. Bol³  Max A. Laansma⁴  Wilma D. J. van de Berg⁵  Maud M. A. Bouwman⁶  Irene Frigerio⁶  Chen-Pei Lin⁶  Laura E. Jonkman⁶  Dagmar H. Hepp⁷ 

[1] Amsterdam Neuroscience, Brain Imaging, Amsterdam, The Netherlands;Department of Radiology and Nuclear Medicine, Amsterdam UMC Location Vrije Universiteit Amsterdam, De Boelelaan 1117, Amsterdam, The Netherlands;Institutes of Neurology and Healthcare Engineering, University College London, London, UK;Department of Pathology, Amsterdam UMC Location Vrije Universiteit Amsterdam, De Boelelaan 1117, Amsterdam, The Netherlands;Section Clinical Neuroanatomy and Biobanking, Department of Anatomy and Neurosciences, Amsterdam UMC Location Vrije Universiteit Amsterdam, De Boelelaan 1118, Amsterdam, The Netherlands;Section Clinical Neuroanatomy and Biobanking, Department of Anatomy and Neurosciences, Amsterdam UMC Location Vrije Universiteit Amsterdam, De Boelelaan 1118, Amsterdam, The Netherlands;Amsterdam Neuroscience, Brain Imaging, Amsterdam, The Netherlands;Section Clinical Neuroanatomy and Biobanking, Department of Anatomy and Neurosciences, Amsterdam UMC Location Vrije Universiteit Amsterdam, De Boelelaan 1118, Amsterdam, The Netherlands;Amsterdam Neuroscience, Neurodegeneration, Amsterdam, The Netherlands;Section Clinical Neuroanatomy and Biobanking, Department of Anatomy and Neurosciences, Amsterdam UMC Location Vrije Universiteit Amsterdam, De Boelelaan 1118, Amsterdam, The Netherlands;Amsterdam Neuroscience, Neurodegeneration, Amsterdam, The Netherlands;Amsterdam Neuroscience, Brain Imaging, Amsterdam, The Netherlands;Section Clinical Neuroanatomy and Biobanking, Department of Anatomy and Neurosciences, Amsterdam UMC Location Vrije Universiteit Amsterdam, De Boelelaan 1118, Amsterdam, The Netherlands;Department of Neurology, Amsterdam UMC Location Vrije Universiteit Amsterdam, De Boelelaan 1117, Amsterdam, The Netherlands;

关键词: Neurofilament;    NfL;    Axonal degeneration;    Parkinson’s disease;    Parkinson’s disease dementia;    Dementia with Lewy bodies;    Cortical thickness;    Cortical atrophy;    Mean diffusivity;   

DOI  :  10.1186/s40035-022-00328-8

 received in 2022-09-13, accepted in 2022-11-17,  发布年份 2022

来源: Springer

【 授权许可】

CC BY   
© The Author(s) 2023

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