High resolution dermal ultrasound (US) combined with superficial radiation therapy (SRT) versus non-image guided SRT or external beam radiotherapy (XRT) in early-stage epithelial cancer: a comparison of studies

BMC Cancer

Research

Songzhu Zheng¹  Lio Yu²  Mairead Moloney³  James Rogers⁴ 

[1] Department of Applied Mathematics and Statistics, Stony Brook University, Stony Brook, NY, USA;Laserderm Dermatology, 327 Middle Country Rd, 11787, Smithtown, NY, USA;New York Institute of Technology College of Osteopathic Medicine, Old Westbury, NY, USA;Summit Analytical LLC, Denver, CO, USA;

关键词: Non-melanoma skin cancer;    Superficial radiation therapy;    Image-guidance;    Statistics;    Local control;    Comparison;   

DOI  :  10.1186/s12885-023-10577-z

 received in 2022-09-08, accepted in 2023-01-24,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundTo compare the effectiveness of high-resolution dermal ultrasound (US) guided superficial radiotherapy (SRT) to non-image-guided radiotherapy in the treatment of early-stage Non-Melanoma Skin Cancer (NMSC).MethodsA high-resolution dermal ultrasound (US) image guided form of superficial radiation therapy (designated here as US-SRT) was developed in 2013 where the tumor configuration and depth can be visualized prior to, during, and subsequent to treatments, using a 22 megahertz (MHz) dermal ultrasound (US) with a doppler component. We previously published the results using this technology to treat 2917 early-stage epithelial cancers showing a high local control (LC) rate of 99.3%. We compared these results with similar American studies from a comprehensive literature search used in an article/guideline published by American Society of Radiation Oncology (ASTRO) on curative radiation treatment of basal cell carcinoma (BCC), squamous cell carcinoma (SCC) and squamous cell carcinoma in-situ (SCCIS) lesions from 1988 to 2018. Only U.S. based studies with greater than 100 cases with similar patient/lesion characteristics and stages treated by external beam, electron, or superficial/orthovoltage radiation therapy were included in the criteria for selection. The resultant 4 studies had appropriate comparable cases identified and the data analyzed/calculated with regard to local control. Logistic regression analysis was performed comparing each study to US-SRT individually and collectively with stratification by histology (BCC, SCC, and SCCIS).ResultsUS-SRT LC was found to be statistically superior to each of the 4 non-image-guided radiation therapy studies individually and collectively (as well as stratified by histology subtype) with p-values ranging from p < 0.0001 to p = 0.0438.ConclusionsResults of US-SRT in local control were statistically significantly superior across the board versus non-image-guided radiation modalities in treatment of epithelial NMSC and should be considered a new gold standard for treatment of early-stage cutaneous BCC, SCC, and SCCIS.

【 授权许可】

CC BY   
© The Author(s) 2023

【 图 表 】

Fig. 5

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