HIV infection of non-classical cells in the brain

Retrovirology

Review

Lena Al-Harthi¹  Angela Wahl² 

[1]Department of Microbial Pathogens and Immunity, Rush University Medical Center, Chicago, IL, USA

[2]International Center for the Advancement of Translational Science, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA

[3]Division of Infectious Diseases, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA

[4]Center for AIDS Research, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA

关键词: HIV;    CNS;    Brain;    Astrocyte;    Microglia;    Non-classical cells;    Neuroinvasion;    Latency;   

DOI  :  10.1186/s12977-023-00616-9

 received in 2022-10-12, accepted in 2023-01-02,  发布年份 2023

来源: Springer

【 摘 要 】

HIV-associated neurological disorders (HAND) affect up to 50% of people living with HIV (PLWH), even in the era of combination antiretroviral therapy (cART). HIV-DNA can be detected in the cerebral spinal fluid (CSF) of approximately half of aviremic ART-suppressed PLWH and its presence is associated with poorer neurocognitive performance. HIV DNA + and HIV RNA + cells have also been observed in postmortem brain tissue of individuals with sustained cART suppression. In this review, we provide an overview of how HIV invades the brain and HIV infection of resident brain glial cells (astrocytes and microglia). We also discuss the role of resident glial cells in persistent neuroinflammation and HAND in PLWH and their potential contribution to the HIV reservoir. HIV eradication strategies that target persistently infected glia cells will likely be needed to achieve HIV cure.

【 授权许可】

CC BY   
© The Author(s) 2023

【 图 表 】

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Fig. 16