Susceptibility of human glial cells to infection with human immunodeficiency virus (HIV)

FEBS Letters

Bresser, Joel¹  Stevenson, Mario³  Evinger-Hodges, Mary Jean²  Volsky, David J.³  Dewhurst, Stephen³  Sakai, Koji³ 

[1] Clinical Immunology and Biological Therapy, M.D. Anderson Hospital and Tumor Institute, Texas Medical Center, 6723 Bertner Avenue, Houston, TX 77030, USA;Department of Hematology, M.D. Anderson Hospital and Tumor Institute, Texas Medical Center, 6723 Bertner Avenue, Houston, TX 77030, USA;Molecular Biology Laboratory, Department of Pathology and Microbiology, University of Nebraska Medical Center, 42nd & Dewey Avenue, Omaha, NE 68105, USA

关键词: AIDS;    Central nervous system;    HIV receptor;    Glial fibrillary acidic protein;    Human immunodeficiency virus;    Astrocyte;    HIV;    human immunodeficiency virus;    AIDS;    acquired immune deficiency syndrome;    GFAP;    glial fibrillary acidic protein;    CNS;    central nervous system;   

DOI  :  10.1016/0014-5793(87)81479-5

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Three human brain-derived cell lines (including two of astrocytic origin) were exposed in vitro to the human immunodeficiency virus (HIV), the etiologic agent of immunodeficiency in AIDS. In all three lines, HIV transcripts were detected by in situ hybridisation in 20–30% of cells 48 h afterinfection. Synthesis of virus gag gene products p24 and p55 was demonstrated by immunoblotting. No cytopathic effects typical of HIV-infected human T lymphocytes were observed. Our data indicate that HIV is neurotropic, and support the hypothesis that this virus may infect astrocytes in the brain.

【 授权许可】

Unknown