Stress hyperglycemia ratio and in-hospital prognosis in non-surgical patients with heart failure and type 2 diabetes

Cardiovascular Diabetology

Research

Qingyang Shi¹  Ye Zhu²  Si Wang²  Jidong He³  Heling Yao³  Li Liu³  Xiaochi Tang⁴  Hongmei Huang⁴  Haoming Tian⁵  Yiling Zhou⁵  Sheyu Li⁶  Xiangyang Chen⁷  Furong Qu⁸  Yuping Zeng⁹  Baihai Su^1,10  Shengzhao Zhang^1,11  Chi Shu^1,12  Nan Li^1,13  Miye Wang^1,13 

[1] Chinese Evidence-Based Medicine Center, Cochrane China Center and MAGIC China Center, West China Hospital, Sichuan University, 610041, Chengdu, China;Department of Cardiology, West China Hospital, Sichuan University, 610041, Chengdu, China;Department of Endocrinology and Metabolism, Second People’s Hospital of Ya’an City, 625000, Ya’an, China;Department of Endocrinology and Metabolism, The First People’s Hospital of Shuangliu District, 610200, Chengdu, China;Department of Endocrinology and Metabolism, West China Hospital, Sichuan University, 610041, Chengdu, China;Department of Endocrinology and Metabolism, West China Hospital, Sichuan University, 610041, Chengdu, China;Chinese Evidence-Based Medicine Center, Cochrane China Center and MAGIC China Center, West China Hospital, Sichuan University, 610041, Chengdu, China;Department of Endocrinology and Metabolism, West China Hospital, Sichuan University, 610041, Chengdu, China;Department of Endocrinology and Metabolism, The First People’s Hospital of Shuangliu District, 610200, Chengdu, China;Department of Endocrinology and Metabolism, West China Hospital, Sichuan University, 610041, Chengdu, China;Department of General Practice, West China Hospital, Sichuan University, 610041, Chengdu, China;Department of Laboratory Medicine, West China Hospital, Sichuan University, 610041, Chengdu, China;Department of Nephrology, West China Hospital, Sichuan University, 610041, Chengdu, China;Department of Pharmacy, Karamay Central Hospital, 834000, Karamay, China;Department of Pharmacy, West China Hospital, Sichuan University, 610041, Chengdu, China;Department of Vascular Surgery, West China Hospital, Sichuan University, 610041, Chengdu, China;The Informatic Center, West China Hospital, Sichuan University, 610041, Chengdu, China;

关键词: Heart failure;    Type 2 diabetes;    Stress hyperglycemia;    Acute kidney injury;    Death;    Cardiovascular events;    Hospitalization;   

DOI  :  10.1186/s12933-022-01728-w

 received in 2022-10-10, accepted in 2022-12-15,  发布年份 2022

来源: Springer

【 摘 要 】

ObjectiveTo evaluate the impact of stress hyperglycemia on the in-hospital prognosis in non-surgical patients with heart failure and type 2 diabetes.Research design and methodsWe identified non-surgical hospitalized patients with heart failure and type 2 diabetes from a large electronic medical record-based database of diabetes in China (WECODe) from 2011 to 2019. We estimated stress hyperglycemia using the stress hyperglycemia ratio (SHR) and its equation, say admission blood glucose/[(28.7 × HbA1c)− 46.7]. The primary outcomes included the composite cardiac events (combination of death during hospitalization, requiring cardiopulmonary resuscitation, cardiogenic shock, and the new episode of acute heart failure during hospitalization), major acute kidney injury (AKI stage 2 or 3), and major systemic infection.ResultsOf 2875 eligible Chinese adults, SHR showed U-shaped associations with composite cardiac events, major AKI, and major systemic infection. People with SHR in the third tertile (vs those with SHR in the second tertile) presented higher risks of composite cardiac events ([odds ratio, 95% confidence interval] 1.89, 1.26 to 2.87) and major AKI (1.86, 1.01 to 3.54). In patients with impaired kidney function at baseline, both SHR in the first and third tertiles anticipated higher risks of major AKI and major systemic infection.ConclusionsBoth high and low SHR indicates poor prognosis during hospitalization in non-surgical patients with heart failure and type 2 diabetes.

【 授权许可】

CC BY   
© The Author(s) 2022

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