Associations between migraine and major cardiovascular events in type 2 diabetes mellitus

Cardiovascular Diabetology

Research

Ye Seul Yang¹  Jong-Hee Sohn²  Chulho Kim²  Sang-Hwa Lee²  Kyung-Ho Yu³  Minwoo Lee³  Byung-Chul Lee³  Mi Sun Oh³  Yerim Kim⁴  Kyungdo Han⁵  Dae Young Cheon⁶ 

[1] Department of Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea;Department of Neurology, Chuncheon Sacred Heart Hospital, Chuncheon, Korea;Department of Neurology, Hallym University Sacred Heart Hospital, Anyang, Korea;Department of Neurology, Kangdong Sacred Heart Hospital, Seoul, Korea;Department of Statistics and Actuarial Science, Soongsil University, Seoul, Korea;Division of Cardiology, Department of Internal Medicine, Dongtan Sacred Heart Hospital, Hwaseong, Korea;

关键词: Migraine;    Diabetes mellitus;    Stroke;    Myocardial infarction;    Cardiovascular death;   

DOI  :  10.1186/s12933-022-01705-3

 received in 2022-09-12, accepted in 2022-11-22,  发布年份 2022

来源: Springer

【 摘 要 】

BackgroundMigraine is one of the most common primary headache disorders and a well-known risk factor for cardiovascular disorders. We aimed to investigate the association between migraine and major cardiovascular outcomes, including myocardial infarction (MI), ischemic stroke (IS), and cardiovascular death (CVD) in people with type 2 diabetes.Research design and methodsA total of 2,229,598 people from the nationwide Korean National Health Insurance Service database with type 2 diabetes but without a previous history of MI and IS were included in this study. We identified patients over 20 years of age with migraine using the claim data of International Statistical Classification of Diseases Related Health Problems, Tenth Revision (ICD-10) code G43. The patients with migraine were divided according to their migraine aura status.ResultsMigraine was present in 6.3% of the study population. Cases observed for MI, IS, CVD, and all-cause death were 2.6%, 3.6%, 5.9%, and 7.9%, respectively. The diagnosis of migraine was significantly associated with an increased risk of MI, IS, and CVD. The results remained significant after adjusting for covariates, including age, sex, body mass index, alcohol intake, smoking habits, physical activity, economic status, hypertension history, dyslipidemia, and duration of type 2 diabetes (MI, adjusted hazard ratio [aHR]: 1.182, 95% confidence interval [CI]: 1.146–1.219; IS, aHR: 1.111, 95% CI 1.082–1.14; CVD, aHR: 1.143, 95% CI 1.12–1.167). In particular, the presence of aura was associated with a higher risk of MI development compared to the non-aura group. The difference became more prominent with progressing age.ConclusionsIn this nationwide population-based study, people with type 2 diabetes and migraines were found to be at a significantly higher risk for major cardiovascular events, including MI, IS, and CVD. The risk of MI and CVD significantly increased with the presence of aura symptoms among patients with migraine.

【 授权许可】

CC BY   
© The Author(s) 2022

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