Clinical characteristics and risk factors for a prolonged length of stay of patients with asymptomatic and mild COVID-19 during the wave of Omicron from Shanghai, China

BMC Infectious Diseases

Research

Yu-Kai Liu¹  Yu-Qiang Fang¹  Zheng Du²  Qi-Di Sun³  Fei Guo³  Fan Zeng⁴  Yuan Cen⁵  Yu-Bo Wang⁶  Yong He⁶  Chen Hu⁶ 

[1] Department of Cardiology, Daping Hospital, Army Medical University, Chongqing, China;National Exhibition and Convention Center Makeshift Hospital, Shanghai, China;Department of Intensive Care Unit, Daping Hospital, Army Medical University, Chongqing, China;Department of Medical Education, Daping Hospital, Army Medical University, Chongqing, China;National Exhibition and Convention Center Makeshift Hospital, Shanghai, China;Department of Neurology and Center for Clinical Neuroscience, Daping Hospital, Army Medical University, Changjiang Branch Road 10, 400042, Chongqing, China;National Exhibition and Convention Center Makeshift Hospital, Shanghai, China;Department of Orthopedics, Daping Hospital, Army Medical University, Changjiang Branch Road 10, 400042, Chongqing, China;Department of Respiratory Disease, Daping Hospital, Army Medical University, Chongqing, China;National Exhibition and Convention Center Makeshift Hospital, Shanghai, China;

关键词: COVID-19;    Omicron;    Clinical characteristic;    Length of stay;    Risk factor;   

DOI  :  10.1186/s12879-022-07935-w

 received in 2022-08-27, accepted in 2022-12-08,  发布年份 2022

来源: Springer

【 摘 要 】

BackgroundThis study aims to investigate the clinical characteristics and the length of hospital stay (LOS), as well as risk factors for prolonged LOS in a cohort of asymptomatic and mild COVID-19 patients infected with the Omicron variant.MethodsA total of 1166 COVID-19 patients discharged from the inpatient ward of the largest makeshift hospital (May 8–10, 2022) in Shanghai, China, were included. The demographics, medical history, and the lowest and admission cycle threshold (Ct) values of the RT-PCR tests for SARS-CoV-2 genes of the open reading frame 1ab (Ct-ORF) and the nucleocapsid protein (Ct-N) during hospitalization were recorded. Patients with LOS > 7 days, or LOS ≤ 7 days were included in the Prolonged group or the Control group, separately. The clinical characteristics and LOS of the participants in the two groups were described and compared. Multivariate Logistic and linear regression analyses were applied to explore the risk factors for prolonged LOS. The diagnostic efficacy of the lowest and admission Ct values for the Prolonged group was tested via the receiver operating characteristic (ROC) curve analysis.ResultsThe median LOS was 6 days in the total study population. The age was older (45.52 ± 14.78 vs. 42.54 ± 15.30, P = 0.001), while both the lowest and admission Ct-ORF (27.68 ± 3.88 vs. 37.00 ± 4.62, P < 0.001; 30.48 ± 5.03 vs. 37.79 ± 3.81, P < 0.001) and Ct-N (25.79 ± 3.60 vs. 36.06 ± 5.39, P < 0.001; 28.71 ± 4.95 vs. 36.95 ± 4.59, P < 0.001) values were significantly lower in the Prolonged group. There were more mild cases in the Prolonged group (23.8% vs. 11.5%, P < 0.001). The symptom spectrum differed between the two groups. In multivariate analyses, age, disease category, and the lowest Ct-N values were shown to be associated with prolonged LOS. Besides, both the lowest and admission Ct-ORF (AUC = 0.911 and 0.873) and Ct-N (AUC = 0.912 and 0.874) showed robust diagnostic efficacy for prolonged LOS.ConclusionsOur study firstly reports the clinical characteristics and risk factors for prolonged LOS during the wave of the Omicron epidemic in Shanghai, China. These findings provide evidence for the early identification of asymptomatic and mild COVID-19 patients at a high risk of prolonged hospitalization who may require early intervention, and long-term monitoring and management.

【 授权许可】

CC BY   
© The Author(s) 2022

【 图 表 】

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Fig. 1