Infectious Disease Reports | 卷:14 |
Conservation and Enhanced Binding of SARS-CoV-2 Omicron Spike Protein to Coreceptor Neuropilin-1 Predicted by Docking Analysis | |
Santi M. Mandal1  Dinata Roy2  Adam G. Schrum3  Piyush Baindara3  | |
[1] Central Research Facility, Indian Institute of Technology Kharagpur, Kharagpur 721302, West Bengal, India; | |
[2] Department of Zoology, Mizoram University, Aizawl 796004, Mizoram, India; | |
[3] Departments of Molecular Microbiology & Immunology, Surgery, and Biomedical, Biological, & Chemical Engineering, School of Medicine, College of Engineering, University of Missouri, Columbia, MO 65211, USA; | |
关键词: SARS-CoV-2; Omicron; spike protein; neuropilin-1; CendR; COVID-19; | |
DOI : 10.3390/idr14020029 | |
来源: DOAJ |
【 摘 要 】
The Omicron variant of SARS-CoV-2 bears peptide sequence alterations that correlate with a higher infectivity than was observed in the original SARS-CoV-2 isolated from Wuhan, China. We analyzed the CendR motif of spike protein and performed in silico molecular docking with neuropilin-1 (Nrp1), a receptor–ligand interaction known to support infection by the original variant. Our analysis predicts conserved and slightly increased energetic favorability of binding for Omicron CendR:Nrp1. We propose that the viral spike:Nrp1 coreceptor pathway may contribute to the infectivity of the Omicron variant of SARS-CoV-2.
【 授权许可】
Unknown