The association between dietary amino acids and the risk of nonalcoholic fatty liver disease among Tehranian adults: a case-control study

BMC Nutrition

Research

Azadeh Mohammadebrahim¹  Samaneh Sadat Bahrololomi¹  Hamid Ahmadirad²  Parvin Mirmiran²  Farshad Teymoori³  Ebrahim Mokhtari⁴ 

[1] Department of Nutrition, health and treatment center of shahriyar, Iran University of Medical Sciences, Tehran, Iran;Nutrition and Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, P.O. Box: 1985717413, Tehran, Iran;Nutrition and Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, P.O. Box: 1985717413, Tehran, Iran;Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran;Student Research Committee, Nutrition and Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran;Nutrition and Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, P.O. Box: 1985717413, Tehran, Iran;

关键词: Amino acids;    NAFLD;    BCAA;    Diet;    Iran;   

DOI  :  10.1186/s40795-022-00656-y

 received in 2022-07-26, accepted in 2022-12-20,  发布年份 2022

来源: Springer

【 摘 要 】

BackgroundAmino acids (AAs) are important bioactive components in the diet that can be involved in various underlying biological processes that contribute to the development of nonalcoholic fatty liver disease (NAFLD). The present study investigates the association between dietary intake of amino acids and NAFLD in Iranian adults.MethodsThis study was conducted among 225 newly diagnosed cases of NAFLD and 450 controls. A valid and reliable 168-item semiquantitative food frequency questionnaire (FFQ) was used to collect participants’ dietary intakes. Multivariable logistic regression models were used to assess the association between tertiles of branched-chain amino acids (BCAAs), aromatic amino acids (AAAs), and sulfuric amino acids (SAAs) intake with the odds of NAFLD among the study participants.ResultsThe mean ± standard deviation of age and BMI of participants (53% male) were 38.1 ± 8.8 years and 26.8 ± 4.3 kg/m2, respectively. In the final models, the OR and 95% CI of NAFLD among participants in the highest tertiles of BCAAs, AAAs, and SAAs intake compared with those in the lowest tertiles were (OR = 2.82; 95% CI: 1.50–5.30), (OR = 2.82; 95% CI: 1.50–5.30), (OR = 2.86; 95% CI: 1.49–5.48), respectively.ConclusionOur study indicated a direct association between the intake of AAs groups, including BCAAs, AAAs, SAAs, and the odds of NAFLD. We suggest that other researchers examine the association between AAs groups and NAFLD in large cohort studies.

【 授权许可】

CC BY   
© The Author(s) 2022

【 图 表 】

Fig. 4