An overview of amines as nutritional supplements to counteract cancer cachexia

Journal of Cachexia, Sarcopenia and Muscle

de Campos-Ferraz Patrícia Lopes¹  Andrade Isabel¹  das Neves Willian¹  Hangai Isabela¹  Alves Christiano Robles Rodrigues¹ 

[1] University of São Paulo, School of Physical Education and Sport, São Paulo, SP

关键词: Muscle atrophy;    Wasting disease;    Amino acids;    BCAA;    Creatine;   

DOI  :  10.1007/s13539-014-0138-x

来源: Wiley

【 摘 要 】

Abstract

Cancer cachexia is a complex multifactorial syndrome characterized by loss of skeletal muscle mass (with or without loss of fat mass) that cannot be fully reversed by conventional nutritional support and leads to progressive functional impairment. Recently, some amino acids and other amine dietary supplements have been highlighted in medical field due to positive effects upon diseases evolving skeletal muscle atrophy. Therefore, the aim of this brief review is to discuss the putative application of amines as dietary supplements to counteract skeletal muscle wasting on cancer cachexia. Specifically, we focus in two nutritional supplements: (1) branched-chain amino acids (BCAAs) and (2) creatine. Both BCAAs and creatine may attenuate proteolysis and enhance proteins synthesis in skeletal muscle. Although more experimental studies and clinical trials are still necessary to elucidate this therapeutic application, several evidences have demonstrated that amines supplementation is a promising coadjuvant treatment to cancer cachexia.

【 授权许可】

CC BY-NC   
© 2014 The Authors. Published by John Wiley & Sons Ltd on behalf of the Society on Sarcopenia, Cachexia and Wasting Disorders

Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.