Black phosphorous-based biomaterials for bone defect regeneration: a systematic review and meta-analysis

Journal of Nanobiotechnology

Review

Narsimha Mamidi¹  Quanchang Tan²  Xiaofan Hu²  Jinfeng Huang²  Zixiang Wu²  Hao Bai²  Ana Cláudia Santos³ 

[1] Department of Chemistry and Nanotechnology, School of Engineering and Science, Tecnologico de Monterrey, 64849, Monterrey, NL, Mexico;Department of Orthopaedics, Xijing Hospital, The Air Force Medical University, 710032, Xi’an, Shaanxi, People’s Republic of China;Department of Pharmaceutical Technology, Faculty of Pharmacy of the University of Coimbra, University of Coimbra, Coimbra, Portugal;REQUIMTE/LAQV, Group of Pharmaceutical Technology, Faculty of Pharmacy of the University of Coimbra, University of Coimbra, Coimbra, Portugal;

关键词: Black phosphorous;    Biomaterials;    Bone regeneration;    Evidence-based research;   

DOI  :  10.1186/s12951-022-01735-9

 received in 2022-10-22, accepted in 2022-12-01,  发布年份 2022

来源: Springer

【 摘 要 】

Critical-sized bone defects are always difficult to treat, and they are associated with a significant burden of disease in clinical practice. In recent decades, due to the fast development of biomaterials and tissue engineering, many bioinspired materials have been developed to treat large bone defects. Due to the excellent osteoblastic ability of black phosphorous (BP), many BP-based biomaterials have been developed to treat bone defects. Therefore, there are abundant studies as well as a tremendous amount of research data. It is urgent to conduct evidence-based research to translate these research data and results into validated scientific evidence. Therefore, in our present study, a qualitative systematic review and a quantitative meta-analysis were performed. Eighteen studies were included in a systematic review, while twelve studies were included in the meta-analysis. Our results showed that the overall quality of experimental methods and reports of biomaterials studies was still low, which needs to be improved in future studies. Besides, we also proved the excellent osteoblastic ability of BP-based biomaterials. But we did not find a significant effect of near-infrared (NIR) laser in BP-based biomaterials for treating bone defects. However, the quality of the evidence presented by included studies was very low. Therefore, to accelerate the clinical translation of BP-based biomaterials, it is urgent to improve the quality of the study method and reporting in future animal studies. More evidence-based studies should be conducted to enhance the quality and clinical translation of BP-based biomaterials.

【 授权许可】

CC BY   
© The Author(s) 2022

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