Peptidomimetics in cancer targeting

Molecular Medicine

Review

Taha Ghantab Pour¹  Babak Ghobari²  Neda Rostami³  Shadi Abkhiz⁴  Mohammad Mahmoudi Gomari⁴  Mona Mosavi⁴  Ehsan Lotfi⁴  Nikolay V. Dokholyan⁵  Fatemeh Nafe Monfared⁶  Behruz Alipour⁷ 

[1] Department of Anatomy, School of Medicine, Iran University of Medical Sciences, Tehran, Iran;Department of Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran;Department of Chemical Engineering, Faculty of Engineering, Arak University, Arak, Iran;Department of Medical Biotechnology, Faculty of Allied Medicine, Iran University of Medical Sciences, Tehran, Iran;Department of Pharmacology, Penn State College of Medicine, Hershey, PA, USA;Department of Biochemistry & Molecular Biology, Penn State College of Medicine, Hershey, PA, USA;Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran;Medical Biotechnology Department, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran;

关键词: Peptidomimetic;    Angiogenesis;    Nanoparticles;    Drug resistance;    Metastasis;    Apoptosis;   

DOI  :  10.1186/s10020-022-00577-3

 received in 2022-08-04, accepted in 2022-11-16,  发布年份 2022

来源: Springer

【 摘 要 】

The low efficiency of treatment strategies is one of the main obstacles to developing cancer inhibitors. Up to now, various classes of therapeutics have been developed to inhibit cancer progression. Peptides due to their small size and easy production compared to proteins are highly regarded in designing cancer vaccines and oncogenic pathway inhibitors. Although peptides seem to be a suitable therapeutic option, their short lifespan, instability, and low binding affinity for their target have not been widely applicable against malignant tumors. Given the peptides’ disadvantages, a new class of agents called peptidomimetic has been introduced. With advances in physical chemistry and biochemistry, as well as increased knowledge about biomolecule structures, it is now possible to chemically modify peptides to develop efficient peptidomimetics. In recent years, numerous studies have been performed to the evaluation of the effectiveness of peptidomimetics in inhibiting metastasis, angiogenesis, and cancerous cell growth. Here, we offer a comprehensive review of designed peptidomimetics to diagnose and treat cancer.

【 授权许可】

CC BY   
© The Author(s) 2022

【 图 表 】

12888_2022_4137_Article_IEq1.gif

12982_2022_119_Article_IEq32.gif

12982_2022_119_Article_IEq24.gif

12982_2022_119_Article_IEq8.gif