Overview of the meningeal lymphatic vessels in aging and central nervous system disorders

Cell & Bioscience

Review

Huimin Wei¹  Xuechun Xiao¹  Chen Zhou²  Yifan Zhou²  Huimin Jiang²  Xunming Ji³ 

[1] Beijing Advanced Innovation Center for Big Data-Based Precision Medicine, School of Biological Science and Medical Engineering, Beihang University, 100191, Beijing, China;Beijing Institute of Brain Disorders, Laboratory of Brain Disorders, Ministry of Science and Technology, Collaborative Innovation Center for Brain Disorders, Beijing Advanced Innovation Center for Big Data-Based Precision Medicine, Capital Medical University, 100069, Beijing, China;Beijing Institute of Brain Disorders, Laboratory of Brain Disorders, Ministry of Science and Technology, Collaborative Innovation Center for Brain Disorders, Beijing Advanced Innovation Center for Big Data-Based Precision Medicine, Capital Medical University, 100069, Beijing, China;Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, 100053, Beijing, China;

关键词: Meningeal lymphatic vessels;    Aging;    Neurological disorders;    Lymphatic drainage;    Central nervous system;   

DOI  :  10.1186/s13578-022-00942-z

 received in 2022-10-17, accepted in 2022-12-13,  发布年份 2022

来源: Springer

【 摘 要 】

In the aging process and central nervous system (CNS) diseases, the functions of the meningeal lymphatic vessels (MLVs) are impaired. Alterations in MLVs have been observed in aging-related neurodegenerative diseases, brain tumors, and even cerebrovascular disease. These findings reveal a new perspective on aging and CNS disorders and provide a promising therapeutic target. Additionally, recent neuropathological studies have shown that MLVs exchange soluble components between the cerebrospinal fluid (CSF) and interstitial fluid (ISF) and drain metabolites, cellular debris, misfolded proteins, and immune cells from the CSF into the deep cervical lymph nodes (dCLNs), directly connecting the brain with the peripheral circulation. Impairment and dysfunction of meningeal lymphatics can lead to the accumulation of toxic proteins in the brain, exacerbating the progression of neurological disorders. However, for many CNS diseases, the causal relationship between MLVs and neuropathological changes is not fully clear. Here, after a brief historical retrospection, we review recent discoveries about the hallmarks of MLVs and their roles in the aging and CNS diseases, as well as potential therapeutic targets for the treatment of neurologic diseases.

【 授权许可】

CC BY   
© The Author(s) 2022

【 图 表 】

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