Rostral cranial fossa as a site for cerebrospinal fluid drainage – volumetric studies in dog breeds of different size and morphotype

BMC Veterinary Research

Karolina Barszcz¹  Marta Kupczyńska¹  Norbert Czubaj¹  Michał Skibniewski¹  Wojciech Sokołowski¹  Zdzisław Kiełbowicz²  Wojciech Kinda² 

[1] Department of Morphological Sciences, Faculty of Veterinary Medicine, Warsaw University of Life Sciences – SGGW;Department of Surgery, Faculty of Veterinary Medicine, Wroclaw University of Environmental and Life Sciences;

关键词: Hydrocephalus;    Lymphatic drainage;    Cerebrospinal fluid;    Dog;    Rostral cranial fossa;    Cribriform plate;   

DOI  :  10.1186/s12917-018-1483-3

来源: DOAJ

【 摘 要 】

Abstract Background Hydrocephalus is a multifactorial condition, whose aetiology is not fully understood. Congenital hydrocephalus frequently occurs in small and brachycephalic dog breeds. Although it is widely accepted that the cribriform plate located in the rostral cranial fossa (RCF) is a site of cerebrospinal fluid (CSF) drainage, the RCF has not been studied extensively. Literature reports indicate that a decreased caudal cranial fossa (CCF) volume in the course of the Chiari-like malformation may obstruct CSF circulation. We hypothesised that morphological diversity among different breeds in the volume of the RCF may affect CSF circulation. The aim of the study was to carry out a volumetric analysis of the RCF and the cranial cavity and to determine the ratio between them in dog breeds of different size and morphotype. We performed computed tomography (CT) morphometric analysis of the RCF compartment by obtaining volume measurements from the transverse and reformatted sagittal and dorsal planes. Results The rostral cranial fossa percentage – volume of the rostral cranial fossa/volume of cranial cavity × 100 (volRCF/volCC × 100) was lower in small and brachycephalic dog breeds than in the other dogs. Conclusions A reduced RCF volume was detected in small and brachycephalic dog breeds, some of which are predisposed to congenital hydrocephalus. This may lead to overcrowding of brain parenchyma in the RCF and may impede CSF circulation. Our observations may be useful for future studies focusing on the causes and new therapies to treat conditions such as hydrocephalus and syringomyelia.

【 授权许可】

Unknown