Association of cardiometabolic risk factors with insulin resistance in overweight and obese children

BMC Endocrine Disorders

Research

Fatemeh Aghamahdi¹  Elnaz Daneshzad²  Mostafa Qorbani³  Armita Mahdavi-Gorabi⁴  Sayeh Rostami⁵ 

[1] Department of Pediatric Endocrinology, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran;Probiotic Research Center, Alborz University of Medical Sciences, Karaj, Iran;Non-Communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran;Non-Communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran;Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran;Probiotic Research Center, Alborz University of Medical Sciences, Karaj, Iran;Student Research Committee, Alborz University of Medical Sciences, Karaj, Iran;

关键词: Cardiometabolic risk factors;    Insulin resistance;    Overweight;    Obesity;    Child;   

DOI  :  10.1186/s12902-022-01245-7

 received in 2021-09-09, accepted in 2022-10-17,  发布年份 2022

来源: Springer

【 摘 要 】

IntroductionRegarding the increased prevalence of obesity among children and adolescents, and the impact of obesity on insulin resistance (IR) and other metabolic disorders, this study was performed to determine the association of cardiometabolic risk factors (CMRFs) with IR in overweight and obese children.MethodIn this cross-sectional study 150 overweight and obese children (BMI ≥ 85th and BMI ≥ 95th age-sex specific percentile) and adolescents were selected via convenient sampling method from Endocrinology clinic in Karaj; Iran in 2020. Anthropometric indices, lipid profile, fasting blood glucose (FBG), and Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) were evaluated. IR was defined as HOMA-IR ≥ 2.6. Multivariable linear and logistic regression model was used to assess the association of CMRFs with insulin level and IR respectively.ResultsThe mean age of children was 10.37 (± 2.6) years. Fifty-four percent of the participants were girls. IR was increased through increasing age (P < 0.001). In the multivariate logistic regression model, by increasing each unit increment in waist circumference (OR: 1.03, 95% CI: 1.01–1.06), wrist circumference (OR: 1.47, 95% CI: 1.06–2.02) total cholesterol (OR: 1.01, 95% CI: 1.003–1.03) and FBG (OR: 1.11, 95% CI: 1.05–1.18) the odds of IR increased significantly. Moreover, in the adjusted linear regression model, HOMA-IR was associated significantly with waist to height ratio (β: 2.45), and FBG (β: 0.02).ConclusionThere was a significant association between some CMRFS with IR in overweight and obese children.

【 授权许可】

CC BY   
© The Author(s) 2022

【 图 表 】

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