Natural essential oils as a new therapeutic tool in colorectal cancer

Cancer Cell International

Review

Darline Dize¹  Barbara Alarcón-Zapata²  Pedro Alarcón-Zapata³  Sara Vitalini⁴  Patrick Valere Tsouh Fokou⁵  Marcello Iriti⁶  Daniela Calina⁷  Stefania Garzoli⁸  Miquel Martorell⁹  Guillermo Cásedas^1,10  Francisco Les^1,11  Víctor López^1,11  Javad Sharifi Rad^1,12  Gulnaz Seitimova^1,13  Eda Sönmez Gürer^1,14  Lauve Rachel Tchokouaha Yamthe^1,15  Raffaele Pezzani^1,16  Farukh Sharopov^1,17 

[1] Antimicrobial and Biocontrol Agents Unit, Department of Biochemistry, Faculty of Science, University of Yaounde 1, Ngoa Ekelle, 812, Yaounde, Cameroon;Clinical Biochemistry and Immunology Department, Faculty of Pharmacy, University of Concepción, Concepción, VIII – Bio Bio Region, Chile;Clinical Biochemistry and Immunology Department, Faculty of Pharmacy, University of Concepción, Concepción, VIII – Bio Bio Region, Chile;Facultad de Ciencias de La Salud, Universidad San Sebastián, Lientur 1457, 4080871, Concepción, Chile;Department of Agricultural and Environmental Sciences, Università Degli Studi di Milano, Via G. Celoria 2, 20133, Milan, Italy;Department of Biochemistry, Faculty of Science, University of Bamenda, 39, Bambili, Cameroon;Department of Biomedical, Surgical and Dental Sciences, Università Degli Studi di Milano, Via G. Pascal 36, 20133, Milan, Italy;Department of Clinical Pharmacy, University of Medicine and Pharmacy of Craiova, 200349, Craiova, Romania;Department of Drug Chemistry and Technologies, University “Sapienza” of Rome, P.Le Aldo Moro 5, 00185, Rome, Italy;Department of Nutrition and Dietetics, Faculty of Pharmacy, and Centre for Healthy Living, University of Concepción, 4070386, Concepción, Chile;Department of Pharmacy, Faculty of Health Sciences, Universidad San Jorge, 50830, Villanueva de Gállego (Saragossa), Spain;Department of Pharmacy, Faculty of Health Sciences, Universidad San Jorge, 50830, Villanueva de Gállego (Saragossa), Spain;Instituto Agroalimentario de Aragón-IA2 (CITA-Universidad de Zaragoza), 50059, Saragossa, Spain;Facultad de Medicina, Universidad del Azuay, Cuenca, Ecuador;Faculty of Chemistry and Chemical Technology, Al-Farabi Kazakh National University, Almaty, Kazakhstan;Faculty of Pharmacy, Department of Pharmacognosy, Sivas Cumhuriyet University, Sivas, Turkey;Institute for Medical Research and Medicinal Plants Studies, 13033, Yaoundé, Cameroon;Phytotherapy Lab (PhT-Lab), Endocrinology Unit, Department of Medicine (DIMED), University of Padova, Via Ospedale 105, 35128, Padua, Italy;AIROB, Associazione Italiana Per la Ricerca Oncologica Di Base, Padua, Italy;Research Institution “Chinese-Tajik Innovation Center for Natural Products”, National Academy of Sciences of the Republic of Tajikistan, Ayni 299/2, 734063, Dushanbe, Tajikistan;

关键词: Colorectal cancer;    Natural essential oils;    Anticancer properties;    Cytotoxicity;    Apoptosis;    Anticancer therapy;   

DOI  :  10.1186/s12935-022-02806-5

 received in 2022-10-09, accepted in 2022-11-24,  发布年份 2022

来源: Springer

【 摘 要 】

Colorectal cancer (CRC) is the third most revalent type of cancer in the world and the second most common cause of cancer death (about 1 million per year). Historically, natural compounds and their structural analogues have contributed to the development of new drugs useful in the treatment of various diseases, including cancer. Essential oils are natural odorous products made up of a complex mixture of low molecular weight compounds with recognized biological and pharmacological properties investigated also for the prevention and treatment of cancer. The aim of this paper is to highlight the possible role of essential oils in CRC, their composition and the preclinical studies involving them. It has been reviewed the preclinical pharmacological studies to determine the experimental models used and the anticancer potential mechanisms of action of natural essential oils in CRC. Searches were performed in the following databases PubMed/Medline, Web of science, TRIP database, Scopus, Google Scholar using appropriate MeSH terms. The results of analyzed studies showed that EOs exhibited a wide range of bioactive effects like cytotoxicity, antiproliferative, and antimetastatic effects on cancer cells through various mechanisms of action. This updated review provides a better quality of scientific evidence for the efficacy of EOs as chemotherapeutic/chemopreventive agents in CRC. Future translational clinical studies are needed to establish the effective dose in humans as well as the most suitable route of administration for maximum bioavailability and efficacy. Given the positive anticancer results obtained from preclinical pharmacological studies, EOs can be considered efficient complementary therapies in chemotherapy in CRC.

【 授权许可】

CC BY   
© The Author(s) 2022

【 图 表 】

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