TREM2 dependent and independent functions of microglia in Alzheimer’s disease

Molecular Neurodegeneration

Review

Marco Colonna¹  Gary Grajales-Reyes¹  Jinchao Hou¹  Yun Chen² 

[1] Department of Pathology and Immunology, Washington University School of Medicine, 63110, St. Louis, MO, USA;Department of Pathology and Immunology, Washington University School of Medicine, 63110, St. Louis, MO, USA;Department of Neurology, Washington University School of Medicine, 63110, St. Louis, MO, USA;

关键词: Alzheimer’s disease;    Beta-amyloid pathology;    Tauopathy;    Demyelination;    Microglia;    TREM2;    APOE;   

DOI  :  10.1186/s13024-022-00588-y

 received in 2021-11-29, accepted in 2022-12-02,  发布年份 2022

来源: Springer

【 摘 要 】

Microglia are central players in brain innate immunity and have been the subject of extensive research in Alzheimer’s disease (AD). In this review, we aim to summarize the genetic and functional discoveries that have advanced our understanding of microglia reactivity to AD pathology. Given the heightened AD risk posed by rare variants of the microglial triggering receptor expressed on myeloid cells 2 (TREM2), we will focus on the studies addressing the impact of this receptor on microglia responses to amyloid plaques, tauopathy and demyelination pathologies in mouse and human. Finally, we will discuss the implications of recent discoveries on microglia and TREM2 biology on potential therapeutic strategies for AD.

【 授权许可】

CC BY   
© The Author(s) 2022

【 图 表 】

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