LINE-1 hypomethylation is associated with poor outcomes in locoregionally advanced oropharyngeal cancer

Clinical Epigenetics

Research

Stefania Corrado¹  Gianluca Businello²  Maria Guido³  Carlo Furlan⁴  Vittorio Baggio⁵  Elisa D’Angelo⁶  Salvatore Romeo⁷  Emanuela Vaccher⁸  Vittorio Giacomarra⁹  Valentina Lupato⁹  Sandro Sulfaro^1,10  Giovanni Franchin^1,11  Giuseppe Fanetti^1,11  Irene Turturici^1,11  Giorgio Giurato^1,12  Annamaria Salvati^1,13  Alessandro Weisz^1,13  Luca Sigalotti^1,14  Riccardo Dolcetti^1,15  Paolo Boscolo-Rizzo^1,16  Polesel Jerry^1,17  Mariateresa Casarotto^1,18  Agostino Steffan^1,18  Lorena Baboci^1,18  Roberto Guerrieri^1,18  Barbara Montico^1,18  Elisabetta Fratta^1,19  Anna Menegaldo^2,20 

[1] Department of Anatomy and Pathology, University Hospital of Modena, Modena, Italy;Department of Pathology, Treviso Regional Hospital, Treviso, Italy;Department of Pathology, Treviso Regional Hospital, Treviso, Italy;Department of Medicine (DIMED), University of Padova, Padova, Italy;Department of Radiation Oncology, General Hospital “San Martino”, Belluno, Italy;Department of Radiation Oncology, Treviso Regional Hospital, Treviso, Italy;Department of Radiation Oncology, University Hospital of Modena, Modena, Italy;Department of Services of Diagnosis and Care, Santorso Hospital, Santorso, VI, Italy;Division of Medical Oncology A, Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, Aviano, Italy;Division of Otolaryngology, General Hospital “S. Maria Degli Angeli”, Pordenone, Italy;Division of Pathology, General Hospital “S. Maria Degli Angeli”, Pordenone, Italy;Division of Radiotherapy, Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, Aviano, PN, Italy;Laboratory of Molecular Medicine and Genomics, Department of Medicine, Surgery and Dentistry ‘Scuola Medica Salernitana’, University of Salerno, Baronissi, SA, Italy;Genome Research Center for Health, Campus of Medicine, University of Salerno, Baronissi, SA, Italy;Laboratory of Molecular Medicine and Genomics, Department of Medicine, Surgery and Dentistry ‘Scuola Medica Salernitana’, University of Salerno, Baronissi, SA, Italy;Genome Research Center for Health, Campus of Medicine, University of Salerno, Baronissi, SA, Italy;Medical Genomics Program, AOU ‘SS. Giovanni di Dio e Ruggi d’Aragona’, University of Salerno, Salerno, Italy;Oncogenetics and Functional Oncogenomics Unit, Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, Aviano, Italy;Peter MacCallum Cancer Centre, 3000, Melbourne, VIC, Australia;Sir Peter MacCallum Department of Oncology, The University of Melbourne, 3010, Melbourne, VIC, Australia;Department of Microbiology and Immunology, The University of Melbourne, 3010, Melbourne, VIC, Australia;Section of Otolaryngology, Department of Neurosciences, University of Padova, Treviso, Italy;Unit of Cancer Epidemiology, Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, Aviano, Italy;Unit of Immunopathology and Cancer Biomarkers, Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, Aviano, Italy;Unit of Immunopathology and Cancer Biomarkers, Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, Aviano, Italy;Division of Immunopathology and Cancer Biomarkers, Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, Via Franco Gallini, 2, 33081, Aviano, PN, Italy;Unit of Otolaryngology, AULSS 2 - Marca Trevigiana, Treviso, Italy;

关键词: Oropharyngeal squamous cell carcinoma;    HPV;    LINE-1;    DNA methylation;    p53;   

DOI  :  10.1186/s13148-022-01386-5

 received in 2022-08-02, accepted in 2022-11-22,  发布年份 2022

来源: Springer

【 授权许可】

CC BY   
© The Author(s) 2022

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