P16 and HPV discordance in metastatic carcinoma of cervical lymph nodes of unknown primary

Clinical Case Reports

Alyssa Ralph²  Andrew Meyer¹  Ronald Sirota³ 

[1] Division of Hematology and Oncology, Advocate Lutheran General Hospital, Park Ridge, Chicago, Illinois, USA;Department of Medicine, Advocate Lutheran General Hospital, Park Ridge, Chicago, Illinois, USA;Division of Pathology, Advocate Lutheran General Hospital, Park Ridge, Chicago, Illinois, USA

关键词: HPV;    Oropharyngeal squamous cell carcinoma;    P16;    Unknown primary;   

DOI  :  10.1002/ccr3.338

来源: Wiley

【 摘 要 】

Key Clinical Message

The prognostic utility of HPV in oropharyngeal squamous cell carcinoma (OPSCC) and non-OPSCC as has been well documented. Currently, a standardized IHC scoring system does not exist and is needed to define HPV positivity. We have recently seen a patient that provides a caution in using p16 status as a diagnostic aid.

【 授权许可】

CC BY-NC   
© 2015 The Authors. Clinical Case Reports published by John Wiley & Sons Ltd.

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