Waist–hip ratio measured by bioelectrical impedance analysis as a valuable predictor of chronic kidney disease development

BMC Nephrology

卷:23

Research

Younghoon Song¹  Ji Eun Kim¹  Jaeun Shin¹  Jeong Ah Hwang¹  Eunjung Cho¹  Gang Jee Ko²  Young Joo Kwon²  Shin Young Ahn² 

[1] Department of Internal Medicine, Korea University Guro Hospital, Gurodong-Ro 148, Guro-Gu, Seoul, South Korea;

[2] Department of Internal Medicine, Korea University Guro Hospital, Gurodong-Ro 148, Guro-Gu, Seoul, South Korea;Department of Internal Medicine, Korea University College of Medicine, Seoul, South Korea;

关键词: Bioelectrical impedance analysis;    Body mass index;    Chronic kidney disease;    Obesity;   

DOI  :  10.1186/s12882-022-02981-7

 received in 2022-07-01, accepted in 2022-09-30,  发布年份 2022

来源: Springer

【 摘 要 】

Obesity is a major health problem worldwide and is associated with chronic kidney disease (CKD). Body mass index (BMI) is a common method of diagnosing obesity, but there are concerns about its accuracy and ability to measure body composition. This study evaluated the risk of CKD development in a middle-aged population in association with various body composition metrics. From a prospective cohort of 10,030 middle-aged adults, we enrolled 6727 for whom baseline and follow-up data were available. We collected data pertaining to participants' BMI, manually measured waist–hip ratio (WHR), and various measurements of bioelectrical impedance analysis (BIA), including total body fat content, muscle content, and calculated WHR, and classified the participants into quintiles accordingly. CKD was defined as an estimated glomerular filtration rate (eGFR) < 60 ml/min/1.73 m2 in follow-up laboratory tests. While an increase in BMI, WHR, and total body fat were associated with an elevated risk of CKD, an increase in total body muscle decreased the risk. Among the body composition metrics, WHR measured by BIA had the highest predictive value for CKD (C-statistics: 0.615). In addition, participants who were “healthy overweight, (defined as low WHR but high BMI), exhibited a 62% lower risk of developing CKD compared to those with “normal-weight obesity,” (defined as high WHR despite a normal BMI). In conclusion, we suggest that central obesity measured by BIA is a more accurate indicator than BMI for predicting the development of CKD.

【 授权许可】

CC BY   
© The Author(s) 2022

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