Gender difference in relationship between body mass index and development of chronic kidney disease

BMC Research Notes

Johji Kato²  Kenji Kuwasako²  Kazuo Kitamura¹  Ikuo Nomura¹  Hiroshi Komura¹ 

[1] Department of Internal Medicine, Circulatory and Body Fluid Regulation, Faculty of Medicine, Kiyotake, Miyazaki 889-1692, Japan;Frontier Science Research Center, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889-1692, Japan

关键词: General population;    Obesity;    Body mass index;    Chronic kidney disease;   

Others  :  1140827
DOI  :  10.1186/1756-0500-6-463

 received in 2013-07-25, accepted in 2013-11-11,  发布年份 2013

【 摘 要 】

Background

An epidemiological approach to preventing the development or progression of chronic kidney disease (CKD) is necessary, while few effective preventive measures are currently available. We conducted a community-based, cohort study to identify the factors associated with the development of CKD in the general population.

Methods

We examined 1876 local residents of a Japanese community who had an annual health check-up and, of those, 1506 residents judged not to have CKD (473 men and 1033 women) were followed for the development of CKD over 10 years.

Results

The numbers of male and female residents who developed CKD during the follow-up period were 167 (35.3%) and 299 (28.9%), respectively. As compared to those without CKD development, the residents who developed CKD were older, and had a higher body mass index (BMI), systolic blood pressure, and creatinine in both genders. The rate of CKD development in obese female residents was higher than in non-obese women, but such a difference was not noted in male residents. In addition to age and serum creatinine, we identified BMI as an independently significant factor for the development of CKD in women, but not in men.

Conclusions

Increased BMI is a significant risk factor for the development of CKD in women, and there seems to be a gender difference in the association between increased BMI and the development of CKD in the general population.

【 授权许可】

   
2013 Komura et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

【 参考文献 】

• [1]National Kidney Foundation: K/DOQI clinical practice guidelines for chronic kidney disease: evaluation, classification, and stratification. Am J Kidney Dis 2002, 39(2 Suppl 1):S1-S266.
• [2]Levey AS, Coresh J, Balk E, Kausz AT, Levin A, Steffes MW, Hogg RJ, Perrone RD, Lau J, Eknoyan G: National Kidney Foundation practice guidelines for chronic kidney disease: evaluation, classification, and stratification. Ann Intern Med 2003, 139:137-147.
• [3]Sarnak MJ, Levey AS, Schoolwerth AC, Coresh J, Culleton B, Hamm LL, McCullough PA, Kasiske BL, Kelepouris E, Klag MJ, Parfrey P, Pfeffer M, Raij L, Spinosa DJ, Wilson PW: Kidney disease as a risk factor for development of cardiovascular disease: a statement from the American Heart Association Councils on kidney in cardiovascular disease, high blood pressure research, clinical cardiology, and epidemiology and prevention. Hypertension 2003, 42:1050-1065.
• [4]Go AS, Chertow GM, Fan D, McCulloch CE, Hsu CY: Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization. N Engl J Med 2004, 351:1296-1305.
• [5]Ninomiya T, Kiyohara Y, Kubo M, Tanizaki Y, Doi Y, Okubo K, Wakugawa Y, Hata J, Oishi Y, Shikata K, Yonemoto K, Hirakata H, Iida M: Chronic kidney disease and cardiovascular disease in a general Japanese population: the Hisayama study. Kidney Int 2005, 68:228-236.
• [6]The Japanese Society of Nephrology: Clinical practice guidebook for diagnosis and treatment of chronic kidney disease 2012. Jpn J Nephrol 2012, 54:1031-1189.
• [7]Klag MJ, Whelton PK, Randall BL, Neaton JD, Brancati FL, Ford CE, Shulman NB, Stamler J: Blood pressure and end-stage renal disease in men. N Engl J Med 1996, 334:13-18.
• [8]Iseki K, Iseki C, Ikemiya Y, Kinjo K, Takishita S: Risk of developing low glomerular filtration rate or elevated serum creatinine in a screened cohort in Okinawa, Japan. Hypertens Res 2007, 30:167-174.
• [9]Chen J, Muntner P, Hamm LL, Jones DW, Batuman V, Fonseca V, Whelton PK, He J: The metabolic syndrome and chronic kidney disease in U.S. adults. Ann Intern Med 2004, 140:167-174.
• [10]Hallan S, De Mutsert R, Carlsen S, Dekker FW, Aasarød K, Holmen J: Obesity, smoking, and physical inactivity as risk factors for CKD: are men more vulnerable? Am J Kidney Dis 2006, 47:396-405.
• [11]Fox CS, Larson MG, Leip EP, Meigs JB, Wilson PWF, Levy D: Glycemic status and development of kidney disease. The Framingham heart study. Diabetes Care 2005, 28:2436-2440.
• [12]Tanaka H, Shiohira Y, Uezu Y, Higa A, Iseki K: Metabolic syndrome and chronic kidney disease in Okinawa, Japan. Kidney Int 2006, 69:369-374.
• [13]Nguyen S, Hsu CY: Excess weight as a risk factor for kidney failure. Curr Opin Nephrol Hypertens 2007, 16:71-76.
• [14]Kramer H, Luke A, Bidani A, Cao G, Cooper R, McGee D: Obesity and prevalent and incident CKD: the hypertension detection and follow-Up program. Am J Kidney Dis 2005, 46:587-594.
• [15]Yamagata K, Ishida K, Sairenchi T, Takahashi H, Ohba S, Shiigai T, Narita M, Koyama A: Risk factors for chronic kidney disease in a community-based population: a 10-year follow-up study. Kidney Int 2007, 71:159-166.
• [16]Wang Y, Chen X, Song Y, Caballero B, Cheskin LJ: Association between obesity and kidney disease: a systematic review and meta-analysis. Kidney Int 2008, 73:19-33.
• [17]Nomura I, Kato J, Kitamura K: Association between body mass index and chronic kidney disease: a population-based, cross-sectional study of a Japanese community. Vasc Health Risk Manag 2009, 5:315-320.
• [18]Matsuo S, Imai E, Horio M, Yasuda Y, Tomita K, Nitta K, Yamagata K, Tomino Y, Yokoyama H, Hishida A: Revised equations for estimated GFR from serum creatinine in Japan. Am J Kidney Dis 2009, 53:982-992.
• [19]Examination Committee of Criteria for ‘Obesity Disease’ in Japan, Japan Society for the Study of Obesity: New criteria for ‘obesity disease’ in Japan. Circ J 2002, 66:987-992.
• [20]Ishizaka N, Ishizaka Y, Toda E, Koike K, Seki G, Nagai R, Yamakado M: Association between obesity and chronic kidney disease in Japanese: differences in gender and hypertensive status? Hypertens Res 2007, 30:1059-1064.
• [21]Shankar A, Leng C, Chia KS, Koh D, Tai ES, Saw SM, Lim SC, Wong TY: Association between body mass index and chronic kidney disease in men and women: population-based study of Malay adults in Singapore. Nephrol Dial Transplant 2008, 23:1910-1918.
• [22]Hunley TE, Ma LJ, Kon V: Scope and mechanisms of obesity-related renal disease. Curr Opin Nephrol Hypertens 2010, 19:227-234.