Morphological analysis of red blood cells by polychromatic interference microscopy of thin films

18th International Conference PhysicA.SPb

Dyachenko, A.A.^1 ; Malinova, L.I.^2 ; Ryabukho, V.P.^1,3

Saratov State University, 83 Astrakhanskaya ul., Saratov

410012, Russia^1

Saratov State Medical University, 112 Bolshaya Kazachia ul., Saratov

410012, Russia^2

Institute of Precision Mechanics and Control, Russian Academy of Science, 24 Rabochaya ul., Saratov

410028, Russia^3

关键词: Clinical practices;    Descriptive statistics;    General population;    Hematological parameters;    Interference color;    Interference microscopy;    Morphological analysis;    Optical thickness distributions;   

Others  :  https://iopscience.iop.org/article/10.1088/1742-6596/769/1/012018/pdf
DOI  :  10.1088/1742-6596/769/1/012018

来源: IOP

【 摘 要 】

Red blood cells (RBC) distribution width (RDW) is a promising hematological parameter with broadapplications in clinical practice; in various studies RDWhas been shown to be associated with increased risk of heart failure (HF) in general population. It predicts mortality and other major adverse events in HF patients. In this report new method of RDWmeasurement is presented. It's based on interference color analysis of red blood cells in blood smear and further measurement of its optical thickness. Descriptive statistics of the of the RBC optical thickness distribution in a blood smear were used for RDW estimation in every studied sample. Proposed method is considered to be avoiding type II errors and minimizing the variability of measured RDW.