An evaluation of the population characteristics, semen quality, and utilization status of autologous sperm cryopreservation and fertility preservation in for 662 patients: a 6-year monocentric retrospective study

Basic and Clinical Andrology

卷:32

Research Article

Senlin Tian¹  Jianfei Song¹  Nan Wei¹  Bin Li¹  Jiangman Gao²  Liang Zhang²  Chenyao Deng³  Han Wu³  Hui Jiang⁴  Wenhao Tang⁴ 

[1] Department of Reproductive Medicine Center, Peking University Third Hospital, Haidian District, 49 North Garden Road, 100191, Beijing, China;Department of Andrology, Peking University Third Hospital, Haidian District, 49 North Garden Road, 100191, Beijing, China;Department of Human Sperm Bank, Peking University Third Hospital, Haidian District, 49 North Garden Road, 100191, Beijing, China;

[2] Department of Reproductive Medicine Center, Peking University Third Hospital, Haidian District, 49 North Garden Road, 100191, Beijing, China;Department of Human Sperm Bank, Peking University Third Hospital, Haidian District, 49 North Garden Road, 100191, Beijing, China;

[3] Department of Urology, Peking University Third Hospital, Haidian District, 49 North Garden Road, 100191, Beijing, China;Department of Andrology, Peking University Third Hospital, Haidian District, 49 North Garden Road, 100191, Beijing, China;Department of Human Sperm Bank, Peking University Third Hospital, Haidian District, 49 North Garden Road, 100191, Beijing, China;

[4] Department of Urology, Peking University Third Hospital, Haidian District, 49 North Garden Road, 100191, Beijing, China;Department of Reproductive Medicine Center, Peking University Third Hospital, Haidian District, 49 North Garden Road, 100191, Beijing, China;Department of Andrology, Peking University Third Hospital, Haidian District, 49 North Garden Road, 100191, Beijing, China;Department of Human Sperm Bank, Peking University Third Hospital, Haidian District, 49 North Garden Road, 100191, Beijing, China;

关键词: Cancer;    Fertility preservation;    Male;    Onco-fertility;    Semen cryopreservation;    Sperm banking;    Cancer;    Préservation de la fertilité;    Homme;    Onco-fertilité;    Cryoconservation des spermatozoïdes;    Banque de sperme;   

DOI  :  10.1186/s12610-022-00169-5

 received in 2022-04-15, accepted in 2022-07-28,  发布年份 2022

来源: Springer

【 摘 要 】

BackgroundSperm cryopreservation is an effective method of fertility preservation for disease-related and social sperm freezing. In total, 662 subjects (range: 15–65 years-of-age; mean: 33.49 ± 8.79 years-of-age) were included in this study to investigate the population characteristics, semen quality, and usage of autologous sperm preservation patients in Beijing. Of these, 351 were cancer patients (53.02%, 31.14 ± 7.32 years-of-age) and 311 were non-cancer patients (46.98%, 36.14 ± 9.54 years-of-age).ResultsWe found that the number of preservation cases increased steadily from 2015 to 2019; 89.73% of these had a bachelor's degree or above; 54.83%, 41.54%, and 3.63% were single, married, and divorced, respectively. The cases of cancers and oligozoospermia accounted for 71.30% of all patients; therefore, most patients required fertility preservation due to disease. The cancer group had a significantly lower sperm concentration, rate of progressive sperm after the frozen-thawed test, total progressive motility sperm count after the frozen-thawed test, and recovery rate of progressive motile sperm (RRPM) than the non-cancer group (all P < 0.05). Sperm count-related parameters were significantly affected by testicular cancer, while sperm motility-related parameters and RRPM were significantly affected by leukemia. The utilization rate of preserved sperm was 6.34% after 6 to 78 months of follow-up. In terms of fresh or frozen embryo transfer, the clinical pregnancy rate was 56.76% or 50.00%, and the live birth rate was 24.32% or 21.43%, respectively.ConclusionThe need for autologous sperm preservation was dominated by patients with diseases, followed by the need for social sperm freezing. Tumors had a major negative impact on semen quality, and the usage rates of stored semen were at lower level compared to the number of sperm cryopreservation. Medical staff and patients should pay attention to both cognition-action consistency and cost-effectiveness in fertility preservation.

【 授权许可】

CC BY   
© The Author(s) 2022