Utilization of cryopreserved sperm cells based on the indication for storage

Investigative and Clinical Urology

Milaida M. East¹  Erin T. Bird¹  Thomas J. Kuehl¹  Dale A. Ingalsbe¹  Stephanie E. Harris¹  Monica L. Brown¹  Michelle Reyes¹  Graham Luke Machen¹ 

[1] Scott & White Medical Center and Texas A&M Health Science Center College of Medicine;

关键词: Cryopreservation;    Fertility preservation;    Infertility;    Male;    Sperm;   

DOI  :  doi.org/10.4111/icu.2018.59.3.177

来源: DOAJ

【 摘 要 】

Purpose: Cryopreservation of sperm from human semen has been available since the 1950s. The actual utilization of available cryopreservation technology has been infrequently reported. We set out to examine the utilization and outcomes of cryopreserved sperm cells based on the indication for storage. Materials and Methods: A dataset was developed from retrospective review. The purposes for cryopreservation, eventual utilization, and outcomes of use for insemination were recorded. The types of utilization were accumulated as proportions for different purposes. The timing for use of samples for insemination procedures was evaluated using survival statistics. The frequency of patients arranging to destroy samples was also reported. Results: From September 1988 through March 2015, 1442 samples were cryopreserved. Samples were cryopreserved for four primary purposes: infertility treatments focused on intrauterine insemination (IUI) or in vitro fertilization/intracellular injection (IVF/ICSI), for fertility preservation related to cancer treatment, or prior to military deployment. Total utilization rates were 19.3%. Samples cryopreserved for IUI were more likely to be used (64.3%), while samples cryopreserved as backup for IVF/ICSI were more likely to be destroyed (29.8%). Pregnancy rates varied based on the indication and ART used. Pregnancies per cycle were 35% for IVF/ICSI and were 10% for IUI. Conclusions: Cryopreservation of sperm is a valuable and underutilized resource, particularly amongst male cancer patients. This technology can facilitate infertility treatments based on a variety of indications, including deployment—a patient cohort unique to our dataset.

【 授权许可】

Unknown