Health-related quality of life among persons with initial mild, moderate, and severe or critical COVID-19 at 1 and 12 months after infection: a prospective cohort study

BMC Medicine

卷:20

Research Article

Menno D. de Jong¹  Anja Lok²  Eric P. Moll van Charante³  Godelieve de Bree⁴  Hugo D. G. van Willigen⁵  Elke Wynberg⁶  Maria Prins⁶  Udi Davidovich⁷  Hans Knoop⁸  Anouk Verveen⁸  Pythia T. Nieuwkerk⁹ 

[1] Amsterdam Institute for Infection and Immunity, Infectious Diseases, Amsterdam, the Netherlands;Department of Medical Microbiology & Infection Prevention, Amsterdam UMC location University of Amsterdam, Meibergdreef 9, Amsterdam, the Netherlands;

[2] Amsterdam Public Health, Amsterdam, The Netherlands;Department of Psychiatry, Amsterdam UMC location University of Amsterdam, Meibergdreef 9, Amsterdam, the Netherlands;Center for Urban Mental Health, University of Amsterdam, Amsterdam, the Netherlands;

[3] Amsterdam Public Health, Amsterdam, The Netherlands;Department of Public & Occupational Health, Amsterdam UMC location University of Amsterdam, Meibergdreef 9, Amsterdam, the Netherlands;Department of General Practice, Amsterdam UMC location University of Amsterdam, Meibergdreef 9, Amsterdam, the Netherlands;

[4] Department of Infectious Diseases, Amsterdam UMC location University of Amsterdam, Meibergdreef 9, Amsterdam, the Netherlands;Amsterdam Institute for Infection and Immunity, Infectious Diseases, Amsterdam, the Netherlands;

[5] Department of Infectious Diseases, Amsterdam UMC location University of Amsterdam, Meibergdreef 9, Amsterdam, the Netherlands;Amsterdam Institute for Infection and Immunity, Infectious Diseases, Amsterdam, the Netherlands;Department of Medical Microbiology & Infection Prevention, Amsterdam UMC location University of Amsterdam, Meibergdreef 9, Amsterdam, the Netherlands;

[6] Department of Infectious Diseases, Public Health Service of Amsterdam, Amsterdam, the Netherlands;Department of Infectious Diseases, Amsterdam UMC location University of Amsterdam, Meibergdreef 9, Amsterdam, the Netherlands;Amsterdam Institute for Infection and Immunity, Infectious Diseases, Amsterdam, the Netherlands;

[7] Department of Infectious Diseases, Public Health Service of Amsterdam, Amsterdam, the Netherlands;Department of Social Psychology, University of Amsterdam, Amsterdam, the Netherlands;

[8] Department of Medical Psychology (J3-2019-1), Amsterdam UMC location AMC University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, the Netherlands;Amsterdam Public Health, Amsterdam, The Netherlands;

[9] Department of Medical Psychology (J3-2019-1), Amsterdam UMC location AMC University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, the Netherlands;Amsterdam Public Health, Amsterdam, The Netherlands;Amsterdam Institute for Infection and Immunity, Infectious Diseases, Amsterdam, the Netherlands;

关键词: SARS-CoV-2;    COVID-19;    Quality of life;    Health-related quality of life;   

DOI  :  10.1186/s12916-022-02615-7

 received in 2022-06-09, accepted in 2022-10-18,  发布年份 2022

来源: Springer

【 摘 要 】

BackgroundCurrently, there is limited evidence about the long-term impact on physical, social and emotional functioning, i.e. health-related quality of life (HRQL) after mild or moderate COVID-19 not requiring hospitalization. We compared HRQL among persons with initial mild, moderate or severe/critical COVID-19 at 1 and 12 months following illness onset with Dutch population norms and investigated the impact of restrictive public health control measures on HRQL.MethodsRECoVERED, a prospective cohort study in Amsterdam, the Netherlands, enrolled adult participants after confirmed SARS-CoV-2 diagnosis. HRQL was assessed with the Medical Outcomes Study Short Form 36-item health survey (SF-36). SF-36 scores were converted to standard scores based on an age- and sex-matched representative reference sample of the Dutch population. Differences in HRQL over time were compared among persons with initial mild, moderate or severe/critical COVID-19 using mixed linear models adjusted for potential confounders.ResultsBy December 2021, 349 persons were enrolled of whom 269 completed at least one SF-36 form (77%). One month after illness onset, HRQL was significantly below population norms on all SF-36 domains except general health and bodily pain among persons with mild COVID-19. After 12 months, persons with mild COVID-19 had HRQL within population norms, whereas persons with moderate or severe/critical COVID-19 had HRQL below population norms on more than half of the SF-36 domains. Dutch-origin participants had significantly better HRQL than participants with a migration background. Participants with three or more COVID-19 high-risk comorbidities had worse HRQL than part participants with fewer comorbidities. Participants who completed the SF-36 when restrictive public health control measures applied reported less limitations in social and physical functioning and less impaired mental health than participants who completed the SF-36 when no restrictive measures applied.ConclusionsTwelve months after illness onset, persons with initial mild COVID-19 had HRQL within population norms, whereas persons with initial moderate or severe/critical COVID-19 still had impaired HRQL. Having a migration background and a higher number of COVID-19 high-risk comorbidities were associated with worse HRQL. Interestingly, HRQL was less impaired during periods when restrictive public health control measures were in place compared to periods without.

【 授权许可】

CC BY   
© The Author(s) 2022

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